VER-50589
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- $21 - $2806
- Product name: VER-50589
- CAS: 747413-08-7
- MF: C19H17ClN2O5
- MW: 388.8
- EINECS:604-604-1
- MDL Number:MFCD18382095
- Synonyms:VER-50589;5-(5-Chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-3-isoxazolecarboxamide;VER 50589;VER50589;CS-2576;3-Isoxazolecarboxamide, 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-;VER-50589 USP/EP/BP;Apoptosis,VER-50589,HSP,VER 50589,Inhibitor,Heat shock proteins,inhibit;VER-50589, 10 mM in DMSO
54 prices
Selected condition：
Brand
- aablocks
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 500μg
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 10mM*1mLinDMSO(Solution)
- Manufactureraablocks
- Product numberAA00FBG9
- Product descriptionVER-50589 ≥98%
- Packaging1mg
- Price$23
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FBG9
- Product descriptionVER-50589 ≥98%
- Packaging5mg
- Price$48
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FBG9
- Product descriptionVER-50589 ≥98%
- Packaging10mg
- Price$71
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FBG9
- Product descriptionVER-50589 ≥98%
- Packaging25mg
- Price$121
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FBG9
- Product descriptionVER-50589 ≥98%
- Packaging50mg
- Price$205
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FBG9
- Product descriptionVER-50589 ≥98%
- Packaging250mg
- Price$757
- Updated2026-05-28
- Buy
- ManufacturerAmbeed
- Product numberA922584
- Product descriptionVER-50589 99%
- Packaging1mg
- Price$21
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA922584
- Product descriptionVER-50589 99%
- Packaging50mg
- Price$185
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA922584
- Product descriptionVER-50589 99%
- Packaging25mg
- Price$109
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA922584
- Product descriptionVER-50589 99%
- Packaging5mg
- Price$44
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA922584
- Product descriptionVER-50589 99%
- Packaging100mg
- Price$314
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA922584
- Product descriptionVER-50589 99%
- Packaging10mg
- Price$65
- Updated2026-06-05
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001085
- Product description5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-3-ISOXAZOLECARBOXAMIDE 95.00%
- Packaging5MG
- Price$499.82
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001085
- Product description5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-3-ISOXAZOLECARBOXAMIDE 95.00%
- Packaging1MG
- Price$196.35
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3592
- Product descriptionVER-50589
- Packaging5mg
- Price$165
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB3592
- Product descriptionVER-50589
- Packaging1mg
- Price$66
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00FBG9 | VER-50589 ≥98% | 1mg | $23 | 2026-05-28 | Buy |
| aablocks | AA00FBG9 | VER-50589 ≥98% | 5mg | $48 | 2026-05-28 | Buy |
| aablocks | AA00FBG9 | VER-50589 ≥98% | 10mg | $71 | 2026-05-28 | Buy |
| aablocks | AA00FBG9 | VER-50589 ≥98% | 25mg | $121 | 2026-05-28 | Buy |
| aablocks | AA00FBG9 | VER-50589 ≥98% | 50mg | $205 | 2026-05-28 | Buy |
| aablocks | AA00FBG9 | VER-50589 ≥98% | 250mg | $757 | 2026-05-28 | Buy |
| Ambeed | A922584 | VER-50589 99% | 1mg | $21 | 2026-06-05 | Buy |
| Ambeed | A922584 | VER-50589 99% | 50mg | $185 | 2026-06-05 | Buy |
| Ambeed | A922584 | VER-50589 99% | 25mg | $109 | 2026-06-05 | Buy |
| Ambeed | A922584 | VER-50589 99% | 5mg | $44 | 2026-06-05 | Buy |
| Ambeed | A922584 | VER-50589 99% | 100mg | $314 | 2026-06-05 | Buy |
| Ambeed | A922584 | VER-50589 99% | 10mg | $65 | 2026-06-05 | Buy |
| American Custom Chemicals Corporation | INB0001085 | 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-3-ISOXAZOLECARBOXAMIDE 95.00% | 5MG | $499.82 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001085 | 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-3-ISOXAZOLECARBOXAMIDE 95.00% | 1MG | $196.35 | 2021-12-16 | Buy |
| ApexBio Technology | B3592 | VER-50589 | 5mg | $165 | 2026-05-06 | Buy |
| ApexBio Technology | B3592 | VER-50589 | 1mg | $66 | 2026-05-06 | Buy |
Properties
Boiling point :583.0±50.0 °C(Predicted)
Density :1.360±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥38.9 mg/mL in DMSO; insoluble in H2O; ≥57.2 mg/mL in EtOH
pka :7.12±0.25(Predicted)
form :solid
color :White to off-white
Density :1.360±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥38.9 mg/mL in DMSO; insoluble in H2O; ≥57.2 mg/mL in EtOH
pka :7.12±0.25(Predicted)
form :solid
color :White to off-white
Safety Information
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Description
The heat shock proteins (Hsps) act as molecular chaperones. Hsp90 is an abundant protein with roles in protein folding, cell signaling, and cancer. VER-50589 is an isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM. It produces a mean cellular antiproliferative GI50 value of 78 nM when tested against a human cancer cell line panel. Consistent with inhibition of Hsp90, VER-50589 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis. VER-50589 shows favorable pharmacokinetics and impairs tumor growth in animals. Importantly, glioblastoma cells do not acquire resistance to VER-50589 and resistance to other Hsp90 inhibitors does not produce cross-resistance to VER-50589.Related product price
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