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ChemicalBook >> CAS DataBase List >> WYE 354-d3

WYE 354-d3

WYE 354-d3 price.
  • $1760
  • Product name: WYE 354-d3
  • CAS: 1794791-66-4
  • MF: C24H29N7O5
  • MW: 495.54
  • EINECS:
  • MDL Number:
  • Synonyms:WYE 354-d3;4-[6-[4-[[(Methoxy-d3)carbonyl]aMino]phenyl]-4-(4-Morpholinyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]-1-piperidinecarboxylic Acid Methyl Ester
1 prices
Selected condition:
Brand
  • TRC
Package
  • 10mg
  • ManufacturerTRC
  • Product numberW950002
  • Product descriptionWYE354-d3
  • Packaging10mg
  • Price$1760
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TRC W950002 WYE354-d3 10mg $1760 2021-12-16 Buy

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Description

A labelled pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and Akt as the respective substrate (IC50 <200 nM; [ATP] = 100 μM) and effectively blocks cellular phosphorylation of S6K on T389 and Akt on S473 both in cultures and in a murine xenograft model, resulting in a significant suppression of PC3MM2-derived tumor growth (by 86% on day 7; 50 mg/kg, i.p twice per day) in vivo.

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