WYE-354
|
- $27 - $4440
- Product name: WYE-354
- CAS: 1062169-56-5
- MF: C24H29N7O5
- MW: 495.53
- EINECS:-0
- MDL Number:MFCD18074514
- Synonyms:WYE-354;4-[6-[4-[(Methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid methyl ester;methyl 4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate;WYE-354 (Degrasyn);WYE-354;WYE 354; WYE354;Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pip;CS-441;1-Piperidinecarboxylic acid, 4-[6-[4-[(methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-, methyl ester
86 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- TRC
Package
- 10mM*1mLinDMSO(Solution)
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100.00mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 100MG
- 250.00mg
- 250MG
- 1g
- Manufactureraablocks
- Product numberAA008SQ1
- Product descriptionWYE-354 98%
- Packaging1mg
- Price$27
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008SQ1
- Product descriptionWYE-354 98%
- Packaging5mg
- Price$33
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008SQ1
- Product descriptionWYE-354 98%
- Packaging10mg
- Price$57
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008SQ1
- Product descriptionWYE-354 98%
- Packaging50mg
- Price$154
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008SQ1
- Product descriptionWYE-354 98%
- Packaging25mg
- Price$91
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberT93010
- Product descriptionWYE-354 98%
- Packaging100MG
- Price$345
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberT93010
- Product descriptionWYE-354 98%
- Packaging100MG
- Price$345
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberT93010
- Product descriptionWYE-354 98%
- Packaging250MG
- Price$690
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberT93010
- Product descriptionWYE-354 98%
- Packaging250MG
- Price$690
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX7422
- Product descriptionmethyl-4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate
- Packaging250mg
- Price$1091
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA121661
- Product descriptionWye-354 98+%
- Packaging250mg
- Price$764
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA121661
- Product descriptionWye-354 98+%
- Packaging50mg
- Price$220
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA121661
- Product descriptionWye-354 98+%
- Packaging100mg
- Price$369
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA121661
- Product descriptionWye-354 98+%
- Packaging5mg
- Price$36
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA121661
- Product descriptionWye-354 98+%
- Packaging10mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA121661
- Product descriptionWye-354 98+%
- Packaging25mg
- Price$136
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA008SQ1 | WYE-354 98% | 1mg | $27 | 2026-05-28 | Buy |
| aablocks | AA008SQ1 | WYE-354 98% | 5mg | $33 | 2026-05-28 | Buy |
| aablocks | AA008SQ1 | WYE-354 98% | 10mg | $57 | 2026-05-28 | Buy |
| aablocks | AA008SQ1 | WYE-354 98% | 50mg | $154 | 2026-05-28 | Buy |
| aablocks | AA008SQ1 | WYE-354 98% | 25mg | $91 | 2026-05-28 | Buy |
| ACHEMBLOCK | T93010 | WYE-354 98% | 100MG | $345 | 2026-05-25 | Buy |
| ACHEMBLOCK | T93010 | WYE-354 98% | 100MG | $345 | 2026-05-27 | Buy |
| ACHEMBLOCK | T93010 | WYE-354 98% | 250MG | $690 | 2026-05-25 | Buy |
| ACHEMBLOCK | T93010 | WYE-354 98% | 250MG | $690 | 2026-05-27 | Buy |
| AK Scientific | X7422 | methyl-4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate | 250mg | $1091 | 2021-12-16 | Buy |
| Ambeed | A121661 | Wye-354 98+% | 250mg | $764 | 2021-12-16 | Buy |
| Ambeed | A121661 | Wye-354 98+% | 50mg | $220 | 2021-12-16 | Buy |
| Ambeed | A121661 | Wye-354 98+% | 100mg | $369 | 2021-12-16 | Buy |
| Ambeed | A121661 | Wye-354 98+% | 5mg | $36 | 2021-12-16 | Buy |
| Ambeed | A121661 | Wye-354 98+% | 10mg | $65 | 2021-12-16 | Buy |
| Ambeed | A121661 | Wye-354 98+% | 25mg | $136 | 2021-12-16 | Buy |
Properties
Density :1.46
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :≥49.6 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :13.42±0.70(Predicted)
color :White to off-white
InChIKey :IMXHGCRIEAKIBU-UHFFFAOYSA-N
SMILES :N1(C(OC)=O)CCC(N2C3C(C=N2)=C(N2CCOCC2)N=C(C2=CC=C(NC(OC)=O)C=C2)N=3)CC1
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :≥49.6 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :13.42±0.70(Predicted)
color :White to off-white
InChIKey :IMXHGCRIEAKIBU-UHFFFAOYSA-N
SMILES :N1(C(OC)=O)CCC(N2C3C(C=N2)=C(N2CCOCC2)N=C(C2=CC=C(NC(OC)=O)C=C2)N=3)CC1
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of phosphatidylinositol 3-kinase α (IC50 = 1026 nM) and other kinases. WYE-354 induces G1 cell cycle arrest in both rapamycin-sensitive and rapamycin-resistant cancer cell lines, inhibits mTORC1 and mTORC2 in tumor-bearing mice, and reduces tumor growth in nude mice with PTEN-null tumors.Related product price
-
BEZ235 (NVP-BEZ235, Dactolisib)
$12-1871.1 -
KU-0063794
$23-2839 -
1,9-Pyrazoloanthrone
$5-1390
