PFK-015
|
4物価
選択條件：
ブランド
- 富士フイルム和光純薬株式會(huì)社(wako)
- Sigma-Aldrich Japan
パッケージ
- 5mg
- 10mg
- 25mg
- 50mg
- 生産者富士フイルム和光純薬株式會(huì)社(wako)
- 製品番號(hào)W01TOC5339
- 製品説明
- 英語(yǔ)製品説明PFK 15
- 包裝単位10mg
- 価格￥51000
- 更新しました2024-03-01
- 購(gòu)入
- 生産者富士フイルム和光純薬株式會(huì)社(wako)
- 製品番號(hào)W01TOC5339
- 製品説明
- 英語(yǔ)製品説明PFK 15
- 包裝単位50mg
- 価格￥214000
- 更新しました2024-03-01
- 購(gòu)入
- 生産者Sigma-Aldrich Japan
- 製品番號(hào)SML1009
- 製品説明 ≥98% (HPLC)
- 英語(yǔ)製品説明PFK15 ≥98% (HPLC)
- 包裝単位5mg
- 価格￥23900
- 更新しました2024-03-01
- 購(gòu)入
- 生産者Sigma-Aldrich Japan
- 製品番號(hào)SML1009
- 製品説明 ≥98% (HPLC)
- 英語(yǔ)製品説明PFK15 ≥98% (HPLC)
- 包裝単位25mg
- 価格￥76400
- 更新しました2024-03-01
- 購(gòu)入
| 生産者 | 製品番號(hào) | 製品説明 | 包裝単位 | 価格 | 更新時(shí)間 | 購(gòu)入 |
|---|---|---|---|---|---|---|
| 富士フイルム和光純薬株式會(huì)社(wako) | W01TOC5339 | PFK 15 |
10mg | ￥51000 | 2024-03-01 | 購(gòu)入 |
| 富士フイルム和光純薬株式會(huì)社(wako) | W01TOC5339 | PFK 15 |
50mg | ￥214000 | 2024-03-01 | 購(gòu)入 |
| Sigma-Aldrich Japan | SML1009 | ≥98% (HPLC) PFK15 ≥98% (HPLC) |
5mg | ￥23900 | 2024-03-01 | 購(gòu)入 |
| Sigma-Aldrich Japan | SML1009 | ≥98% (HPLC) PFK15 ≥98% (HPLC) |
25mg | ￥76400 | 2024-03-01 | 購(gòu)入 |
プロパティ
沸點(diǎn) :464.4±45.0 °C(Predicted)
比重(密度) :1.237±0.06 g/cm3(Predicted)
貯蔵溫度 :Sealed in dry,2-8°C
溶解性 :DMSO: soluble10mg/mL, clear
酸解離定數(shù)(Pka) :3.11±0.61(Predicted)
外見(jiàn) :powder
色 :white to beige
安定性： :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :1S/C17H12N2O/c20-17(14-9-11-18-12-10-14)8-7-15-6-5-13-3-1-2-4-16(13)19-15/h1-12H/b8-7+
InChIKey :UJJUKZPBUMCSJZ-BQYQJAHWSA-N
SMILES :n1ccc(cc1)C(=O)\C=C\c2nc3c(cc2)cccc3
比重(密度) :1.237±0.06 g/cm3(Predicted)
貯蔵溫度 :Sealed in dry,2-8°C
溶解性 :DMSO: soluble10mg/mL, clear
酸解離定數(shù)(Pka) :3.11±0.61(Predicted)
外見(jiàn) :powder
色 :white to beige
安定性： :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :1S/C17H12N2O/c20-17(14-9-11-18-12-10-14)8-7-15-6-5-13-3-1-2-4-16(13)19-15/h1-12H/b8-7+
InChIKey :UJJUKZPBUMCSJZ-BQYQJAHWSA-N
SMILES :n1ccc(cc1)C(=O)\C=C\c2nc3c(cc2)cccc3
安全情報(bào)
| 絵表示(GHS): |
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| 注意喚起語(yǔ): | Warning | ||||||||||||||||||||||||||||
| 危険有害性情報(bào): |
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| 注意書(shū)き: |
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説明
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) is a bifunctional enzyme that contains distinct domains for the phosphorylation of fructose 6-phosphate and the dephosphorylation of fructose 2,6-bisphosphate. PFKFB3 protein expression is elevated in most tumor types. PFK15 is a selective inhibitor of PFKFB3 (IC50 = 207 nM). It has no significant inhibitory effect on any member of a panel of 96 other kinases, and does not inhibit purified 6-phosphofructo-1-kinase, hexokinase, phosphoglucose isomerase, or PFKFB4. PFK15 rapidly induces apoptosis in transformed cells, suppresses glucose uptake and growth of Lewis lung carcinomas in syngeneic mice, and yields antitumor effects in human xenograft models of cancer in athymic mice.関連商品価格
- 塩酸フェンホルミン
￥7280-446900 - A769662
￥32000-320000 - AVP-AEW541
￥35700-112000
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