sbc-115076
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1物価
選択條件:
ブランド
- Sigma-Aldrich Japan
パッケージ
- 5MG
- 生産者Sigma-Aldrich Japan
- 製品番號SML1712
- 製品説明 ≥98% (HPLC)
- 英語製品説明SBC-115076 ≥98% (HPLC)
- 包裝単位5MG
- 価格¥28200
- 更新しました2024-03-01
- 購入
| 生産者 | 製品番號 | 製品説明 | 包裝単位 | 価格 | 更新時間 | 購入 |
|---|---|---|---|---|---|---|
| Sigma-Aldrich Japan | SML1712 | ≥98% (HPLC) SBC-115076 ≥98% (HPLC) |
5MG | ¥28200 | 2024-03-01 | 購入 |
プロパティ
沸點 :754.2±60.0 °C(Predicted)
比重(密度) :1.266±0.06 g/cm3(Predicted)
貯蔵溫度 :Sealed in dry,Store in freezer, under -20°C
溶解性 :DMSO:46.0(Max Conc. mg/mL);87.18(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.95(Max Conc. mM)
DMF:2.0(Max Conc. mg/mL);3.79(Max Conc. mM) 外見 :A crystalline solid
酸解離定數(shù)(Pka) :4.50±1.00(Predicted)
色 :White to off-white
SMILES :CC1=CC(C(C(C(C2=CC=NC=C2)N3CCCN4CCOCC4)=C(O)C3=O)=O)=CC=C1OCC5=CC=CC=C5
比重(密度) :1.266±0.06 g/cm3(Predicted)
貯蔵溫度 :Sealed in dry,Store in freezer, under -20°C
溶解性 :DMSO:46.0(Max Conc. mg/mL);87.18(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.95(Max Conc. mM)
DMF:2.0(Max Conc. mg/mL);3.79(Max Conc. mM) 外見 :A crystalline solid
酸解離定數(shù)(Pka) :4.50±1.00(Predicted)
色 :White to off-white
SMILES :CC1=CC(C(C(C(C2=CC=NC=C2)N3CCCN4CCOCC4)=C(O)C3=O)=O)=CC=C1OCC5=CC=CC=C5
安全情報
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説明
Proprotein convertase subtilisin kexin 9 (PCSK9) is a member of the subtilisin serine protease family with important roles in lipoprotein metabolism. PCSK9 overexpression in wild-type mice doubles plasma total cholesterol, possibly through acceleration of degradation of the LDL receptor (LDLR). SBC-115076 is an inhibitor of PCSK9 action that blocks LDLR degradation in HEK293T cells expressing PCSK9. Through this mechanism, submicromolar concentrations of SBC-115076 increase the uptake of LDL by liver cells in vitro. SBC-115076 is effective in vivo, lowering cholesterol levels in mice that are fed a high fat diet.供給者とメーカー
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