Product Details
| Product Name:
CA-170 |
CAS No.:
1673534-76-3 |
| Supply Ability:
10g |
Release date:
2026/05/21 |
Product Introduction
Bioactivity
| Name | CA-170 |
| Description | CA-170 is an orally bioavailable dual inhibitor of VISTA and PD-L1 that selectively restores T-cell proliferation and effector function suppressed by immune checkpoint signaling, while demonstrating minimal off-target activity across a broad receptor and enzyme panel, making CA-170 a valuable compound for immuno-oncology research and immune checkpoint modulation studies. |
| In vitro | PD-1 is a co-receptor that is expressed predominantly by T cells. The binding of PD-1 to its ligands, PD-L1 or PD-L2, is important for the physiological regulation of the immune system[1]. |
| In vivo | In preclinical studies using syngeneic mouse tumor models (e.g., colorectal cancer and melanoma), oral administration of CA-170 inhibits tumor growth [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 24 mg/mL (66.61 mM), Sonication is recommended.
|
| Keywords | PD-1 | CA-170 |
| Inhibitors Related | LSD1-IN-24 | PD-1/PD-L1-IN-9 | BMS-1166-n-piperidine-co-n-piperazine dihydrochloride | IMMH 010 maleate | Icariside I | Fraxinellone | Pembrolizumab | LSD1-IN-27 | Acesulfame Potassium | Anti-Mouse PD-1 Antibody (RMP1-14) | Panaxadiol | JQ-1 (carboxylic acid) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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