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Analytical Chemistry

Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Structure Chemical Name CAS MF
BOTRYTISCINEREA BOTRYTISCINEREA 72882-27-0
deoxyfructosazine deoxyfructosazine 17460-13-8 C12H20N2O7
3,5-DIMETHYL 2-CHLORMETHYL PYRIDINE.HCL 3,5-DIMETHYL 2-CHLORMETHYL PYRIDINE.HCL 73590-93-9 C8H11Cl2N
Cetirizine Amide Cetirizine Amide 83881-37-2 C21H26ClN3O2
Dihydro-FK506 Dihydro-FK506 104987-30-6 C44H71NO12
Dehydro Tizanidine Dehydro Tizanidine 125292-34-4 C9H6ClN5S
α-Ribavirin (Ribavirin Impurity B) α-Ribavirin (Ribavirin Impurity B) 57198-02-4 C8H12N4O5
21-Acetoxy-11β-hydroxy-16α,17α-propylmethylenedioxpregna-1,4-diene-3,20-dione 21-Acetoxy-11β-hydroxy-16α,17α-propylmethylenedioxpregna-1,4-diene-3,20-dione 51333-05-2 C27H36O7
Acyclovir EP Impurity M Acyclovir EP Impurity M 91702-60-2 C12H15N5O5
Axitinib Impurity c Axitinib Impurity c 885126-40-9 C22H18N4OS
Nicorandil Impurity Nicorandil Impurity
Empagliflozin Impurity Empagliflozin Impurity 2253771-11-6 C21H25ClO8
Sildenafil EP IMpurity D Sildenafil EP IMpurity D 1357931-55-5 C17H20N4O5S
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-propyl ester 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-propyl ester 1797124-83-4 C38H45N3O6
Edoxaban iMpurities Edoxaban iMpurities 1255529-34-0 C14H27N3O3
TaMsulosin EP IMpurity D TaMsulosin EP IMpurity D 1799280-05-9 C19H26N2O5S
Ticagrelor Sulphone Ticagrelor Sulphone 1788033-05-5 C23H28F2N6O4S
3-Acetyl-17-deacetyl Rocuronium Bromide 3-Acetyl-17-deacetyl Rocuronium Bromide 1190105-63-5 C32H53BrN2O4
1-(3-BroMopropyl)theobroMine 1-(3-BroMopropyl)theobroMine 6493-10-3 C10H13BrN4O2
5-(5-Carboxy-2-ethoxyphenyl)-1-Methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyriMidin-7-one 5-(5-Carboxy-2-ethoxyphenyl)-1-Methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyriMidin-7-one 147676-78-6 C18H20N4O4
FaMotidine Acid IMpurity Methyl Ester FaMotidine Acid IMpurity Methyl Ester 76824-14-1 C9H14N4O2S2
SiMvastatin Hydroxy Acid Ethyl Ester SiMvastatin Hydroxy Acid Ethyl Ester 864357-87-9 C27H44O6
Atomoxetine Related Compound B (10 mg) (N-Methyl-3-phenyl-3-(m-tolyloxy)propan-1-amine hydrochloride) Atomoxetine Related Compound B (10 mg) (N-Methyl-3-phenyl-3-(m-tolyloxy)propan-1-amine hydrochloride) 873310-28-2 C17H22ClNO
(αR,δS)-4-Fluoro-N-(4-fluorophenyl)-δ-hydroxy-α-[(4-hydroxyphenyl)Methyl]benzenepentanaMide (αR,δS)-4-Fluoro-N-(4-fluorophenyl)-δ-hydroxy-α-[(4-hydroxyphenyl)Methyl]benzenepentanaMide 1197811-72-5 C24H23F2NO3
Entacapone EP IMpurity I Entacapone EP IMpurity I 1364322-42-8 C13H12N2O6
(S)-1-(2-Chloroacetyl)pyrrolidine-2-carboxaMide (S)-1-(2-Chloroacetyl)pyrrolidine-2-carboxaMide 214398-99-9 C7H11ClN2O2
5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride 720720-96-7 C8H11ClN2O2S
(S)-2-((6-(3-aMinopiperidin-1-yl)-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)Methyl)benzonitrile (S)-2-((6-(3-aMinopiperidin-1-yl)-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)Methyl)benzonitrile 1353254-15-5 C18H25N3O2
(1S,2R,3R)-Aprepitant (1S,2R,3R)-Aprepitant 1242175-34-3 C23H21F7N4O3
Cefoxitin Impurity 6 Cefoxitin Impurity 6 1422023-32-2 C16H17N3O7S2
Tebipenem pivoxil impurity P6 Tebipenem pivoxil impurity P6 1665289-91-7 C23H33N3O7S2
Rivaroxaban Impurity 28 Rivaroxaban Impurity 28 2489689-18-9 C23H25N3O5
2,2'-(disulfanediylbis(methylene))bis(1-(5-methoxy-1H-benzo[d]imidazol-2-yl)-3,5-dimethylpyridin-4(1H)-one) 2,2'-(disulfanediylbis(methylene))bis(1-(5-methoxy-1H-benzo[d]imidazol-2-yl)-3,5-dimethylpyridin-4(1H)-one) 1803449-02-6 C32H32N6O4S2
Amoxicillin Impurity  N Amoxicillin Impurity N C16H19N3O5S
Olmesartan Impurity 9 Olmesartan Impurity 9 849206-42-4 C10H14N2O2
5-(2-FLUOROPHENYL)-1-(PYRIDIN-2-YLSULFONYL)-1H-PYRROLE-3-CARBALDEHYDE 5-(2-FLUOROPHENYL)-1-(PYRIDIN-2-YLSULFONYL)-1H-PYRROLE-3-CARBALDEHYDE 928324-73-6 C16H11FN2O3S
Butylphthalide impurity Butylphthalide impurity 685886-82-2 C12H15KO3
Pregabalin Impurity 21 Pregabalin Impurity 21 1083246-65-4 C16H32N2O3
Dapoxetine-004 Dapoxetine-004 2245197-07-1 C30H31NO
Dexmedetomidine-004 Dexmedetomidine-004 2240179-62-6 C13H16N2
Flurbiprofen Impurity 6 Flurbiprofen Impurity 6 124635-86-5 C18H19FO4
Dapagliflozin Impurity 9 Dapagliflozin Impurity 9 2305949-36-2 C15H14ClIO
Cilastatin Impurity A Cilastatin Impurity A
1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanol 1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanol 2055542-18-0 C12H18O5S
Metaraminol Bitartrate Impurity 3 Metaraminol Bitartrate Impurity 3 21480-43-3 C9H13NO2
Avatrombopag Impurity 22 Avatrombopag Impurity 22 570403-14-4 C31H38Cl2N6O3S2
Ipratropium Bromide EP Impurity F Bromide Ipratropium Bromide EP Impurity F Bromide 60018-35-1 C20H28BrNO2
7(4H)-Benzothiazolone, 2-amino-5,6-dihydro-6-(propylamino)-, (6S)- 7(4H)-Benzothiazolone, 2-amino-5,6-dihydro-6-(propylamino)-, (6S)- 2204518-89-6 C10H15N3OS
Pramipexole Impurity Z Pramipexole Impurity Z
Posacozole Related Compound 2 Posacozole Related Compound 2 165115-70-8 C11H10F2O2
Carbamic acid, N-[3-fluoro-4-(4-morpholinyl)phenyl]-, 1,1-dimethylethyl ester Carbamic acid, N-[3-fluoro-4-(4-morpholinyl)phenyl]-, 1,1-dimethylethyl ester 952680-48-7 C15H21FN2O3
DEXTROMETHORPHAN IMPURITY A DEXTROMETHORPHAN IMPURITY A 58496-77-8 C17H24BrNO
Clotrimazole EP Impurity G Clotrimazole EP Impurity G 289887-34-9 C23H19ClN2
Ampicillin oxidation impurities Ampicillin oxidation impurities
Pregn-16-en-20-one, 3,12-bis(acetyloxy)-, (3β,5α,12α)- Pregn-16-en-20-one, 3,12-bis(acetyloxy)-, (3β,5α,12α)- 5767-82-8 C25H36O5
Heptanoic acid, 7-bromo-2,2-dimethyl- Heptanoic acid, 7-bromo-2,2-dimethyl- 7443-29-0 C9H17BrO2
Benzamide, 3-[[5-chloro-4-(3-pyridinyl)-2-pyrimidinyl]amino]-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]- Benzamide, 3-[[5-chloro-4-(3-pyridinyl)-2-pyrimidinyl]amino]-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]- 2469039-94-7 C28H21ClF3N7O
methyl N,N,N-trimethyl-4-[(4,7,7-trimethyl-3-oxobicyclo[2.2.1]hept-2-ylidene)methyl]anilinium sulphate methyl N,N,N-trimethyl-4-[(4,7,7-trimethyl-3-oxobicyclo[2.2.1]hept-2-ylidene)methyl]anilinium sulphate 52793-97-2 C21H31NO5S
ethyl 4-hydroxy-2-oxopyrrolidine-1-acetate ethyl 4-hydroxy-2-oxopyrrolidine-1-acetate 62613-81-4 C8H13NO4
Peganine Peganine 6159-56-4 C11H12N2O
Nicergoline Impurity 12 Nicergoline Impurity 12
Rosuvastatin Impurity 156 Rosuvastatin Impurity 156
Acetamide, N-(2-aminoethyl)-2-[(3-hydroxyphenyl)(4-methylphenyl)amino]- Acetamide, N-(2-aminoethyl)-2-[(3-hydroxyphenyl)(4-methylphenyl)amino]- 2724727-52-8 C17H21N3O2
Geclosporin Geclosporin 74436-00-3 C63H113N11O12
1,6-Naphthyridine-3-carboxamide, 4-(4-cyano-2-methoxyphenyl)-1,4-dihydro-2,8-dimethyl-5-(1-methylethoxy)- 1,6-Naphthyridine-3-carboxamide, 4-(4-cyano-2-methoxyphenyl)-1,4-dihydro-2,8-dimethyl-5-(1-methylethoxy)- 2640280-85-7 C22H24N4O3
L-Ampicillin L-Ampicillin 19379-33-0 C16H19N3O4S
ardisiacrispin B ardisiacrispin B 112766-96-8 C53H86O22
3-N-OXALYL-L-2,3-DIAMINOPROPANOICACID 3-N-OXALYL-L-2,3-DIAMINOPROPANOICACID 5302-45-4 C5H8N2O5
2-(2,4-DIHYDROXYBENZOYL)BENZOIC ACID 2-(2,4-DIHYDROXYBENZOYL)BENZOIC ACID 2513-33-9 C14H10O5
SALOR-INT L173312-1EA SALOR-INT L173312-1EA 55917-07-2 C14H21NO
Amlodipine Diethyl Ester Amlodipine Diethyl Ester 140171-65-9 C21H27ClN2O5
Dehydro Simvastatin Dehydro Simvastatin 210980-68-0 C25H36O4
Mono-POC Isopropyl Tenofovir Mono-POC Isopropyl Tenofovir 1422284-15-8 C21H32N5O11P
Cephalexin Diketopiperazine Monoacid (Mixture of DiastereoMers) Cephalexin Diketopiperazine Monoacid (Mixture of DiastereoMers) 1323247-65-9 C16H19N3O5S
2-Des(acetylthioMethyl)-2-Methylene Racecadotril 2-Des(acetylthioMethyl)-2-Methylene Racecadotril 87428-99-7 C19H19NO3
(R)-(4-(5-chlorobenzo[d]oxazol-2-yl)-7-Methyl-1,4-diazepan-1-yl)(5-Methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)Methanone (R)-(4-(5-chlorobenzo[d]oxazol-2-yl)-7-Methyl-1,4-diazepan-1-yl)(5-Methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)Methanone 1030377-80-0 C23H23ClN6O2
Icariside I Icariside I 56725-99-6 C27H30O11
Albuterol diMer Albuterol diMer 147663-30-7 C26H40N2O5
edaravone iMpurity A edaravone iMpurity A
Pantoprazole EP IMpurity E Pantoprazole EP IMpurity E 2115779-15-0 C32H28F4N6O8S2
BUTYL ANALOG OF TAXOL, n-(RG) BUTYL ANALOG OF TAXOL, n-(RG) 173101-55-8 C45H55NO14
Toluene-4-sulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl Toluene-4-sulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl 159811-30-0 C21H21F2N3O4S
Azilsartan iMpurity A Azilsartan iMpurity A 147404-76-0 C25H23N3O4
Apixaban IMpurity 2 Apixaban IMpurity 2 1801881-16-2 C25H25N5O4
Lidocaine IMpurity E Lidocaine IMpurity E 745798-07-6 C20H25N3O2
Dabigatran iMpurity J Dabigatran iMpurity J 211915-00-3 C33H39N7O5
N-(3-(2-(2-chloropyriMidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonaMide N-(3-(2-(2-chloropyriMidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonaMide 1195768-20-7 C18H11ClF3N3O3S
DL-β-O-Methylnorepinephrine Hydrochloride DL-β-O-Methylnorepinephrine Hydrochloride 3770-01-2 C9H14ClNO3
LincoMycin 2-Phosphate LincoMycin 2-Phosphate 27480-30-4 C18H35N2O9PS
((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate ((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate 864070-37-1 C19H21ClO6
Isavuconazole Impurity Isavuconazole Impurity 21661-87-0 C9H5Br2NO
Ceftaroline Fosamil Impurity 8 Ceftaroline Fosamil Impurity 8 1286218-63-0 C22H23N8O9PS4
Sitagliptin EP Impurity C Sitagliptin EP Impurity C 945261-48-3 C16H16F5N5O
3-Thiomorpholinecarboxylic acid, 5-oxo-, 1-oxide 3-Thiomorpholinecarboxylic acid, 5-oxo-, 1-oxide 88620-38-6 C5H7NO4S
Anhydrosafflor yellow B Anhydrosafflor yellow B 184840-84-4 C48H52O26
(4S)-2-(((R)-2-Amino-2-(4-hydroxyphenyl)acetamido)(carboxy)-methyl)-5,5-dimethylthiazolidine-4 (4S)-2-(((R)-2-Amino-2-(4-hydroxyphenyl)acetamido)(carboxy)-methyl)-5,5-dimethylthiazolidine-4 42947-63-7 C16H21N3O6S
2-(tert-butylamino)-1-(4-hydroxy-3-methylphenyl)ethan-1-one 2-(tert-butylamino)-1-(4-hydroxy-3-methylphenyl)ethan-1-one 60853-66-9 C13H19NO2
AmBroxol Impurity 11 AmBroxol Impurity 11 2088879-81-4 C14H16Br2N2O
Fludarabine Phosphate EP Impurity C Fludarabine Phosphate EP Impurity C 548774-53-4 C10H14FN5O10P2
Parecoxib Impurity 4 Parecoxib Impurity 4 57736-10-4 C14H13NO
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