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Analytical Chemistry

Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Structure Chemical Name CAS MF
2-(azidomethyl)-1,3-difluorobenzene 2-(azidomethyl)-1,3-difluorobenzene 106308-60-5 C7H5F2N3
sobutyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5 -carboxylate sobutyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5 -carboxylate 923942-36-3 C20H24N2O3S
[D-PRO2, D-TRP7,9]-SUBSTANCE P [D-PRO2, D-TRP7,9]-SUBSTANCE P 80434-86-2 C74H106N20O13S
ASTRAGALOSIDE ASTRAGALOSIDE 17429-69-5 C28H32O17
Azithromycin F Azithromycin F 612069-26-8 C38H72N2O13
Olaparib Impurity G Olaparib Impurity G
Brivaracetam Impurity B Brivaracetam Impurity B 943986-67-2 C11H19NO3
2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 74936-81-5 C15H14N2O6
Rufinamide Impurity 3 Rufinamide Impurity 3
Apixaban Impurity 24 Apixaban Impurity 24 1928718-22-2 C26H27N5O4
Cisatracurium Besilate impurity Cisatracurium Besilate impurity
((3S,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethyl
sulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate) calcium(II) ((3S,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethyl sulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate) calcium(II) 2185805-14-3 C44H54CaF2N6O12S2
Cefprozil EP Impurity I Cefprozil EP Impurity I C18H19N3O5S
ethyl 2-(4-butoxy-3-formylphenyl)-4-methylthiazole-5-
carboxylate ethyl 2-(4-butoxy-3-formylphenyl)-4-methylthiazole-5- carboxylate 2230270-03-6 C18H21NO4S
1H-Pyrazole-3-Carboxylicacid,4,5-Dihydro-5-Oxo-1-(4-Sulfophenyl)-,3-Ethylester,Sodiumsalt 1H-Pyrazole-3-Carboxylicacid,4,5-Dihydro-5-Oxo-1-(4-Sulfophenyl)-,3-Ethylester,Sodiumsalt 20514-27-6 C12H13N2NaO6S
Peramivir Impurity Peramivir Impurity 383910-24-5 C18H30N2O5
Lincomycin EP Impurity C Lincomycin EP Impurity C 14600-41-0 C17H32N2O6S.ClH
N-SucciniMidoxycarbonyl-β-alanine N-SucciniMidyl Ester N-SucciniMidoxycarbonyl-β-alanine N-SucciniMidyl Ester 21994-89-8 C12H13N3O8
Cefotaxime Impurity L Cefotaxime Impurity L
(2RS)-2-(4-FORMYLPHENYL)PROPANOIC ACID (2RS)-2-(4-FORMYLPHENYL)PROPANOIC ACID 43153-07-7 C10H10O3
Apremilast Impurity HS093313 Apremilast Impurity HS093313 2077897-93-7 C20H21NO6S
Flumethasone Impurity 6 (9-Chloro-Flumethasone) Flumethasone Impurity 6 (9-Chloro-Flumethasone) 1355648-15-5 C22H28ClFO5
3-Quinolinecarboxylic acid, 7-[(4aS,7aS)-1-(2-carboxyethyl)octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo- 3-Quinolinecarboxylic acid, 7-[(4aS,7aS)-1-(2-carboxyethyl)octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo- 2489671-20-5 C24H28FN3O6
Imipenem Impurity 4 Imipenem Impurity 4 85604-01-9 C23H30N4O8S2
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3,5-bis(2-cyanoethyl) ester 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3,5-bis(2-cyanoethyl) ester 75130-34-6 C21H20N4O6
Araloside C Araloside C 55446-15-6 C53H84O23
Sugammadex Sodium Impurity 36 Sugammadex Sodium Impurity 36
8,8'-((3R,3'R)-(methylenebis(azanediyl))bis(piperidine-3,1-diyl))bis(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione) 8,8'-((3R,3'R)-(methylenebis(azanediyl))bis(piperidine-3,1-diyl))bis(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione) 2489212-72-6 C51H56N16O4
Ampicillin Hydantoin Analogs Ampicillin Hydantoin Analogs
Complete set of Ampicillin Impurities Complete set of Ampicillin Impurities
Helicianeoide B Helicianeoide B 496066-89-8 C32H38O20
benazepril benazepril 131064-75-0 C24H28N2O5
1-Cyclohexene-1-carboxylicacid,4-(aminomethyl)-(9CI) 1-Cyclohexene-1-carboxylicacid,4-(aminomethyl)-(9CI) 330838-52-3 C8H13NO2
4-PREGNEN-6-BETA-OL-3,20-DIONE 4-PREGNEN-6-BETA-OL-3,20-DIONE 604-19-3 C21H30O3
uridine 5'-tetraphosphate uridine 5'-tetraphosphate 10003-94-8 C9H16N2O18P4
AMILORIDE AMILORIDE 2609-46-3 C6H8ClN7O
Aztreonam Amide Aztreonam Amide 1219444-93-5 C13H20N6O8S2
N-[2-[(Methylamino)carbonyl]benzoyl] N-[2-[(Methylamino)carbonyl]benzoyl] 721958-72-1 C29H32ClN3O7
3-O-Methylcarbidopa 3-O-Methylcarbidopa 85933-19-3 C11H16N2O4
C-DeMethyl ClethodiM C-DeMethyl ClethodiM 112301-96-9 C16H24ClNO3S
(4S,5S)-4-Benzyl-5-[(2S)-2-((4S)-4-isopropyl-2,5-dioxoiMidazolidin-1-yl)-3-phenylpropyl]-2-oxo-1,3-oxazolidine-3-carboxylate thiazol-5-ylMethyl Ester (4S,5S)-4-Benzyl-5-[(2S)-2-((4S)-4-isopropyl-2,5-dioxoiMidazolidin-1-yl)-3-phenylpropyl]-2-oxo-1,3-oxazolidine-3-carboxylate thiazol-5-ylMethyl Ester 1010809-43-4 C30H32N4O6S
ent-Tadalafil ent-Tadalafil 629652-72-8 C22H19N3O4
6.7-dihydrothieno[3.2.c]pyridin-4(5H)-one 6.7-dihydrothieno[3.2.c]pyridin-4(5H)-one 68559-60-4 C7H7NOS
N-DesaMinosulfonyl-N-cyano FaMotidine N-DesaMinosulfonyl-N-cyano FaMotidine 76823-97-7 C9H13N7S2
6-Des(1-Methyl-2-benziMidazolyl)-6-carboxy TelMisartan 6-Des(1-Methyl-2-benziMidazolyl)-6-carboxy TelMisartan 884330-12-5 C26H24N2O4
ent-Aprepitant ent-Aprepitant 172822-29-6 C23H21F7N4O3
Clarithromycin Impurity H Clarithromycin Impurity H 127140-69-6 C38H67NO14
IMidazo[1,2-a]pyridin-6-aMine, 3-chloro- IMidazo[1,2-a]pyridin-6-aMine, 3-chloro- 1094463-26-9 C7H6ClN3
2-AMino-3-(4-broMobenzoyl)phenyloxoacetic Acid 2-AMino-3-(4-broMobenzoyl)phenyloxoacetic Acid 1391052-54-2 C15H10BrNO4
Micafungin FR-179642 impurity (acid) Micafungin FR-179642 impurity (acid) 168110-44-9 C35H52N8O20S
(3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile (3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile 1640971-60-3 C14H20N6O
AMlodipine iMpurity AMlodipine iMpurity C26H31ClN2O8S
Cephalexin IMpurity C Cephalexin IMpurity C C16H17N3O4S
(R)-AMbrisentan (R)-AMbrisentan 1007358-76-0 C22H22N2O4
1,2-Dithiolane-3-pentanoic acid 1-oxide 1,2-Dithiolane-3-pentanoic acid 1-oxide 6992-30-9 C8H14O3S2
4-(3,4-Dihydro-4,4-dimethyl-7-pentylfuro[4,3,2-de][1]benzopyran-3-yl)-2-butanone 4-(3,4-Dihydro-4,4-dimethyl-7-pentylfuro[4,3,2-de][1]benzopyran-3-yl)-2-butanone 70474-97-4
3'-Demethyl-12-deoxyerythromycin 3'-Demethyl-12-deoxyerythromycin 33442-56-7 C36H65NO12
2-[4-(4-METHOXY-PHENOXY)-PHENYL]-MALONIC ACID MONO-(4-METHOXY-PHENYL) ESTER 2-[4-(4-METHOXY-PHENOXY)-PHENYL]-MALONIC ACID MONO-(4-METHOXY-PHENYL) ESTER 70175-90-5 C25H24O7
5-Desthiolyl-5-thioxo Cefoperazone 5-Desthiolyl-5-thioxo Cefoperazone 711598-76-4 C25H27N9O8S2
Clindamycin 3-Phosphate Clindamycin 3-Phosphate 28708-34-1 C18H34ClN2O8PS
Finasteride IMpurity C Finasteride IMpurity C 1329611-51-9 C23H34N2O2
Ivabradine IMpurity Ivabradine IMpurity 1616710-50-9 C27H35ClN2O6
1,2-Bis(piperazin-1-yl)benzene 1,2-Bis(piperazin-1-yl)benzene 1446750-99-7 C14H22N4
4-Methyl-N-(3-(5-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)phenyl)-3-((4-(pyridin-3-yl)pyriMidin-2-yl)aMino)benzaMide 4-Methyl-N-(3-(5-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)phenyl)-3-((4-(pyridin-3-yl)pyriMidin-2-yl)aMino)benzaMide 641571-15-5 C28H22F3N7O
Pentoxifylline Impurity I Pentoxifylline Impurity I 55247-90-0 C14H14N4O2
Pentoxifylline Impurity I Pentoxifylline Impurity I 55247-90-0 C14H14N4O2
Axitinib Impurity C Axitinib Impurity C
Pregabalin EP Impurity A Pregabalin EP Impurity A 181289-23-6 C8H15NO
Amoxicillin EP Impurity L Amoxicillin EP Impurity L 1789703-32-7 C24H29N5O7S2
Cefotiam Impurity 2 Cefotiam Impurity 2 1566599-01-6 C13H12N4O4S2
Posaconazole Impurity 43 Posaconazole Impurity 43 357189-95-8 C37H40F2N8O6
Tedizolid Impurity 34 Tedizolid Impurity 34 2095200-69-2 C16H18FN6O5P
JYMSVNHODSJOPS-UHFFFAOYSA-N JYMSVNHODSJOPS-UHFFFAOYSA-N 46053-56-9 C8H10N2O2
Levosimendan Impurity 4 Levosimendan Impurity 4 131741-37-2 C14 H14 N6 O2
Nicorandil Impurity 5 Nicorandil Impurity 5 896133-95-2 C8H10N2O3
Ampicillin EP Impurity M Ampicillin EP Impurity M 62326-82-3 C32H38N6O8S2
Diclindamycin Pyrophosphate/Clindamycin Phosphate EP Impurity K Diclindamycin Pyrophosphate/Clindamycin Phosphate EP Impurity K
Amoxicillin  Impurity 3 Amoxicillin Impurity 3 297175-66-7 C31H40N6O9S2
Ceftizoxime sodium Impurity 6 Ceftizoxime sodium Impurity 6
Dapagliflozin Impurity 27 Dapagliflozin Impurity 27
Celecoxib Impurity 23 Celecoxib Impurity 23 2247197-66-4 C18H15F3N2O3S
5-(4-Fluorophenyl)thiophene-2-carboxylic acid 5-(4-Fluorophenyl)thiophene-2-carboxylic acid 115933-30-7 C11H7FO2S
Moxifloxacin Impurity 29 Moxifloxacin Impurity 29 1620445-12-6 C21H22FN3O5
2H-Isoindole-2-butanoic acid, 4-amino-γ-(aminocarbonyl)-1,3-dihydro-1-oxo- 2H-Isoindole-2-butanoic acid, 4-amino-γ-(aminocarbonyl)-1,3-dihydro-1-oxo- 2197414-57-4 C13H15N3O4
Paeoniflorgenin Paeoniflorgenin 697300-41-7 C17H18O6
Reference preparation Reference preparation
Atracurium EP Impurity K Atracurium EP Impurity K
PROPOFOL RELATED COMPOUND C (50 MG) (2,6-DIISOPROPYLPHENYL ISOPROPYLETHER) PROPOFOL RELATED COMPOUND C (50 MG) (2,6-DIISOPROPYLPHENYL ISOPROPYLETHER) 141214-18-8 C15H24O
2-Methyltetrahydropyran 2-Methyltetrahydropyran 10141-72-7 C6H12O
Pyridine, 3-[3-(1-methylethoxy)androsta-5,16-dien-17-yl]- Pyridine, 3-[3-(1-methylethoxy)androsta-5,16-dien-17-yl]- 2484719-15-3 C27H37NO
2-((2-naphthyloxy)methyl)-oxiran 2-((2-naphthyloxy)methyl)-oxiran 5234-06-0 C13H12O2
6-bromo-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride 6-bromo-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride
Acetamide, N-[2-[1-(3,4-diethoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]- Acetamide, N-[2-[1-(3,4-diethoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]- 2448678-64-4 C23H26N2O7S
2-(4-(2-(4-(1-(ethoxymethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoic acid 2-(4-(2-(4-(1-(ethoxymethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoic acid C27H35N3O3
1,6-Naphthyridine-3-carboxamide, 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl- 1,6-Naphthyridine-3-carboxamide, 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl- 2084136-51-4 C21H20N4O3
Ritonavir EP Impurity LNO Ritonavir EP Impurity LNO
1,6-Naphthyridine-3-carboxamide, 4-(4-cyano-2-methoxyphenyl)-1,4-dihydro-5-methoxy-2,8-dimethyl- 1,6-Naphthyridine-3-carboxamide, 4-(4-cyano-2-methoxyphenyl)-1,4-dihydro-5-methoxy-2,8-dimethyl- 2640280-84-6 C20H20N4O3
3-Hydroxy-4,5-dimethoxybenzoic acid 3-Hydroxy-4,5-dimethoxybenzoic acid 1916-08-1 C9H10O5
CYPERENONE CYPERENONE 3466-15-7 C15H22O
Chikusetsu saponin Ib Chikusetsu saponin Ib 59252-87-8 C47H74O18
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