| Company Name: |
Shanghai Rechem science Co., Ltd.
|
| Tel: |
021-31433387 15618786686 |
| Email: |
sales@rechemscience.com |
| Products Intro: |
CAS:2361304-26-7
Purity:98% Package:1g;5g
|
STAT3-IN-3 manufacturers
- STAT3-IN-3
-
- $892.00
-
2026-05-26
- CAS:2361304-26-7
- Purity: 99.49%
- Supply Ability: 10g
- STAT3-IN-3
-
- $892.00
-
2026-05-26
- CAS:2361304-26-7
- Purity: 99.49%
- Supply Ability: 10g
- STAT3-IN-3
-
- $1230.00
-
2025-07-22
- CAS:2361304-26-7
- Purity:
- Supply Ability: 10g
|
| | STAT3-IN-3 Basic information |
| Product Name: | STAT3-IN-3 | | Synonyms: | STAT3-IN-3;STAT3 inhibitor 3;2H-1-Benzopyran-2-one, 3-[[4-[(4-bromo-1,1-dioxidobenzo[b]thien-2-yl)carbonyl]-1-piperazinyl]carbonyl]-7-(diethylamino)-;STAT3IN3,STAT3 IN 3,STAT-3-IN-3 | | CAS: | 2361304-26-7 | | MF: | C27H26BrN3O6S | | MW: | 600.48 | | EINECS: | | | Product Categories: | | | Mol File: | 2361304-26-7.mol |  |
| | STAT3-IN-3 Chemical Properties |
| Boiling point | 915.1±65.0 °C(Predicted) | | density | 1.572±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 5 mg/mL (8.33 mM) | | pka | 3.19±0.20(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | STAT3-IN-3 Usage And Synthesis |
| Uses | STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3), with anti-proliferative activity. STAT3-IN-3 induces apoptosis in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research[1]. | | Biological Activity | STAT3-IN-3 is a potent and selective STAT3 inhibitor with antiproliferative activity. It can induce apoptosis in breast cancer cells. It is a promising mitochondria-targeted STAT3 inhibitor for cancer research. | | in vivo | STAT3-IN-3 (10mg/kg-20 mg/kg; ip; daily; for 14 days) possesses potent antitumor activity against implanted 4T1 breast tumors growth.
| Animal Model: | Adult female BALB/c mice (6 weeks of age) | | Dosage: | 10 mg/kg, 20 mg/kg | | Administration: | Intraperitoneal injection, daily, for 14 days | | Result: | Significantly inhibited tumor volume. | | | target | | | IC 50 | STAT3 | | References | [1] Cai G, et al. Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. Eur J Med Chem. 2019 Jul 15;174:236-251. DOI:10.1016/j.ejmech.2019.04.024 |
| | STAT3-IN-3 Preparation Products And Raw materials |
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