STAT3-IN-3 NEW
| Price | $892 | $1360 | $2190 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-26 |
Product Details
| Product Name: STAT3-IN-3 | CAS No.: 2361304-26-7 |
| Purity: 99.49% | Supply Ability: 10g |
| Release date: 2026/05/26 |
Product Introduction
Bioactivity
| Name | STAT3-IN-3 |
| Description | STAT3-IN-3 is a potent and highly selective targeted STAT3 inhibitor with significant anti-proliferative activity. It effectively induces apoptosis in breast cancer cells. As a mitochondrially targeted STAT3 inhibitor with great research potential, it has good application value in tumor mechanism exploration and anti-cancer research. |
| In vitro | Methods: In vitro cell experiments and molecular biology assays were used to evaluate the effects of STAT3-IN-3 on the phosphorylation levels of STAT3 and its upstream and downstream related kinases, tumor cell proliferation, target gene expression, and STAT3 DNA-binding ability. Meanwhile, the levels of reactive oxygen species (ROS), mitochondrial membrane potential, and cleavage levels of apoptosis-related proteins were detected to clarify its pro-apoptotic mechanism. Results: 1.STAT3-IN-3 did not alter the phosphorylation levels of STAT1, JAK2, Src, and Erk1/2, indicating a certain degree of target specificity in its action. 2.STAT3-IN-3 significantly inhibited the proliferation of various tumor cells, with IC?? values of 1.43 μM, 1.89 μM, 2.88 μM, and 3.33 μM for MDA?MB?231, HCT?116, HepG2, and MCF?7 cells, respectively. 3.STAT3-IN-3 effectively inhibited the tyrosine and serine phosphorylation of STAT3, reduced the DNA-binding activity of STAT3, and downregulated the expression of downstream target genes Bcl-2 and Cyclin D1. 4.Treatment of cells with 1–4 μM STAT3-IN-3 for 24 hours increased intracellular ROS production, decreased mitochondrial membrane potential, thereby activating the mitochondrial apoptotic pathway. Meanwhile, it promoted the cleavage of caspase-9, caspase-3, and PARP proteins, initiating the cellular apoptotic program [1]. |
| In vivo | Methods: A 4T1 breast cancer xenograft animal model was used. STAT3-IN-3 was administered via daily intraperitoneal injection at a dose of 10 mg/kg to 20 mg/kg for 14 consecutive days, and its in vivo antitumor effect was observed and evaluated. Results: STAT3-IN-3 (10–20 mg/kg, intraperitoneal injection once daily for 14 consecutive days) significantly inhibited the growth of 4T1 breast cancer xenografts in vivo, showing good in vivo antitumor activity [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 4 mg/mL (6.66 mM), Sonication is recommended. |
| Keywords | STAT3-IN-3 | STAT-3-IN-3 | STAT3IN3 | STAT3 IN 3 | STAT3 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
-
-
CAS:2668267-41-0
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $196.00 |
VIP6Y
|
TargetMol Chemicals Inc.
|
2026-06-12 | |
| $55.00 |
VIP4Y
|
TargetMol Chemicals Inc.
|
2026-05-11 | |
|
VIP1Y
|
ACROBiosystems
|
2026-07-02 | ||
| $892.00 |
VIP4Y
|
TargetMol Chemicals Inc.
|
2026-05-26 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
INQUIRY