人參皂甙 Rh1
| 中文名稱 | 人參皂甙 Rh1 |
|---|---|
| 中文同義詞 | 人參皂苷-RH1;人參皂苷 S-RH1;人參皂苷RH1(標準品);人參皂苷RH1(S)/20(S)-人參皂苷RH1;(R型)人參皂苷RH1;人參皂莢RH1;(S型)人參皂苷RH1;人參皂苷RH1(S) |
| 英文名稱 | Ginsenoside Rh1 |
| 英文同義詞 | sanchinoside rh1;(3beta,6alpha,12beta)-3,12,20-trihydroxydammar-24-en-6-yl?beta-d-glucopyranoside;GINSENOSIDE RH1;(20S)-6α-(β-D-Glucopyranosyloxy)-3β,12β,20-trihydroxydammara-24-ene;(20S)-6α-(β-D-Glucopyranosyloxy)dammar-24-ene-3β,12β,20-triol;3β,12β,20-Trihydroxy-5α-dammar-24-en-6α-yl β-D-glucopyranoside;6α-(β-D-Glucopyranosyloxy)-dammara-24-ene-3β,12β,20-triol;GINSENOSIDE Rh1(SH) |
| CAS號 | 63223-86-9 |
| 分子式 | C36H62O9 |
| 分子量 | 638.88 |
| EINECS號 | |
| 植物來源 | 人參 |
| 相關(guān)類別 | 中藥對照品;標準品;生化試劑;對照品,標準品;分析標準品;植物提取物;小分子抑制劑,天然產(chǎn)物;中藥標準品;小分子抑制劑;Ginsenoside series;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;對照品;植提標準品;Inhibitors;化學(xué)試劑;生化試劑-其他化學(xué)試劑;標準品-中藥標準品;標準品 -中藥標準品;三萜;分析試劑-對照品 |
| Mol文件 | 63223-86-9.mol |
| 結(jié)構(gòu)式 | ![]() |
人參皂甙 Rh1 性質(zhì)
| 沸點 | 755.1±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.23 |
| 儲存條件 | 2-8°C |
| 溶解度 | DMSO:100 mg/mL(156.53 mM;需要超聲波) |
| 形態(tài) | 粉末 |
| 酸度系數(shù)(pKa) | 12.91±0.70(Predicted) |
| 顏色 | 白色 |
| 主要應(yīng)用 | 食品和飲料 |
| 化妝品成分功效 | 護發(fā)素 皮膚調(diào)理劑 - 保濕劑 |
| InChIKey | RAQNTCRNSXYLAH-CCJJTDGONA-N |
| SMILES | C\C(C)=C/CC[C@](C)(O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]3[C@@]4(C)CC[C@H](O)C(C)(C)[C@@H]4[C@H](C[C@@]23C)O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O |
| LogP | 3.740 (est) |
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PPAR-γ
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TNF-α
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IL-6
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IL-1β
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Human Endogenous Metabolite
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The effect of Ginsenoside Rh1 is examined on adipogenesis in 3T3-L1 cells. Ginsenoside Rh1 potently inhibits the adipogenesis, as assessed by Oil-red O staining and lipid contents in 3T3-L1 adipocytes. Ginsenoside Rh1, at concentrations of 50 μM and 100 μM, inhibit the adipogenesis by 50% and 63%, respectively.The expression levels of adipocytespecific genes such as PPAR-γ, C/EBP-α, FAS, aFABP and some genes are examined during early phase of differentiation such as Pref-1, C/EBP-δ and Glucocorticoid receptor (GR). After the treatment with Ginsenoside Rh1 in 3T3-L1 cells, mRNA is extracted on 18 h and 24 h for Pref-1, C/EBP-δ and GR and day 8 for PPAR-γ, C/EBP-α, FAS, aFABP. Then, the expression profiles of adipocyte-specific genes are investigated by RT-PCR. PPAR-γ, C/EBP-α, FAS, and aFABP expressions are significantly increased in DMI-stimulated differentiated adipocyte compared to those of non-stimulated adipocyte cells. However, treatment with DMI in the presence of Ginsenoside Rh1 significantly suppresses the expression levels of PPAR-γ, C/EBP-α, FAS, and aFABP in a dose- dependent manner, whereas the expression levels of Pref-1, C/EBP-δ and GR are not affected.
When high-fat diet (HFD) fed mice for 8 weeks, body and epididymal fat weight gains are significantly increased compared to those of low-fat diet (LFD)-fed mice. However, when Ginsenoside Rh1 is treated in HFD-fed mice, body and epididymal fat weight gains are significantly decrease compared with those of the HFD-fed mice. TG, glucose, insulin, total cholesterol, and HDL levels in the blood are significantly increased in HFD-fed mice group compared to LFD-fed mice group. Treatment with Ginsenoside Rh1 in HFD-fed mice significantly lowers TG level alone.
藥理藥效:具有滋補強壯,抗腫瘤作用。
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲類別 | 11 - 可燃固體 |
| 危險性類別 | 急性毒性 類別4 經(jīng)口 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/07/06 | S9129 | 人參皂甙 Rh1 20(S)-Ginsenoside Rh1 | 63223-86-9 | 1mg | 1040.63元 |
| 2026/07/06 | S9129 | 人參皂甙 Rh1 20(S)-Ginsenoside Rh1 | 63223-86-9 | 5mg | 3104.01元 |
