兔抗小鼠CTLA-4
| 中文名稱 | 兔抗小鼠CTLA-4 |
|---|---|
| 中文同義詞 | 兔抗小鼠CTLA-4 |
| 英文名稱 | Rabbit Anti-Murine CTLA-4 |
| 英文同義詞 | Rabbit Anti-Murine CTLA-4 |
| CAS號(hào) | |
| 分子式 | |
| 分子量 | 0 |
| EINECS號(hào) | |
| 相關(guān)類別 | 抗體 |
| Mol文件 | Mol File |
| 結(jié)構(gòu)式 |
兔抗小鼠CTLA-4 性質(zhì)
Rabbit
與反應(yīng): Mouse
Recombinant fragment within Mouse CTLA4 aa 1-200. The exact sequence is proprietary.
Unconjugated
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CTLA-4 / CD152 (rM CTLA-4 / CD152; Catalog#50503-M08H; NP_033973.2; Met1-Phe162).
適用于: Flow CytFlow Cytometry - Anti-CTLA4 antibody [EPR21972-205] (ab224295)
Flow cytometric analysis of mouse primary splenocytes treated with ConA (2.5 μg/ml, 3 days) labeling CTLA4 with ab224295 at 1/100 dilution (Right panel) compared with a Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730) (Left panel). Goat anti rabbit IgG (Alexa Fluor® 488, ab150077) at 1/2000 dilution was used as the secondary antibody.
A low level of CTLA4 is expected to be on the cell surface; the majority is intracellular, localized to secretory lysosomes (PMID: 11046036). Gated on viable cells.
Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD8 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).兔抗小鼠CTLA-4是以CTLA-4為抗原的兔多克隆抗體，可以特異性結(jié)合CTLA-4。兔抗小鼠CTLA-4主要用于ICC/IF,Dotblot,ELISA,IHC-P,IHC-Fr,Immunomicroscopy,WB等CTLA-4檢測(cè)實(shí)驗(yàn)。