THI0019 manufacturers
- THI0019
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- $1834.00
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2026-05-11
- CAS:1378532-99-0
- Purity:
- Supply Ability: 10g
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| | THI0019 Basic information | | Uses |
| Product Name: | THI0019 | | Synonyms: | 9-Oxa-4,6,11-triazadodecanoic acid, 3-(1,3-benzodioxol-5-yl)-7-butyl-5,10-dioxo-12-(2-thienyl)-11-(2-thienylmethyl)-, methyl ester, (3S,7S)-;THI0019;THI0019 (3S,7S)-3-(1,3-Benzodioxol-5-yl)-7-butyl-5,10-dioxo-12-(2-
thienyl)-11-(2-thienylmethyl)-9-oxa-4,6,11-
triazadodecanoic acid methyl ester;(3S,7S)-3-(1,3-Benzodioxol-5-yl)-7-butyl-5,10-dioxo-12-(2- thienyl)-11-(2-thienylmethyl)-9-oxa-4,6,11- triazadodecanoic acid methyl ester;Triazadodecanoic acid methyl ester | | CAS: | 1378532-99-0 | | MF: | C29H35N3O7S2 | | MW: | 601.73 | | EINECS: | | | Product Categories: | | | Mol File: | 1378532-99-0.mol |  |
| | THI0019 Chemical Properties |
| | THI0019 Usage And Synthesis |
| Uses | THI0019 is a very late antigen 4 (VLA-4) integrin agonist that induces progenitor cell adhesion. | | Description | THI0019 is an agonist of very late antigen-4 (VLA-4) integrin that induces progenitor cell adhesion. THI0019 greatly enhanced the adhesion of cultured cell lines and primary progenitor cells to α4β1 ligands VCAM-1 and CS1 under both static and flow conditions. Furthermore, THI0019 facilitated the rolling and spreading of cells on VCAM-1 and the migration of cells toward SDF-1α. Molecular modeling predicted that the compound binds at the α/β subunit interface overlapping the ligand-binding site thus indicating that the compound must be displaced upon ligand binding. Co-administering progenitor cells with a compound such as THI0019 may provide a mechanism for enhancing stem cell therapy. |
| | THI0019 Preparation Products And Raw materials |
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