Product Details
| Product Name:
THI0019 |
CAS No.:
1378532-99-0 |
| Supply Ability:
10g |
Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | THI0019 |
| Description | THI0019 is a highly potent agonist of the integrin α4β1 (VLA-4) receptor, with an EC 50 range of 1-2 μM. It effectively promotes the adhesion of stem/progenitor cells. Furthermore, THI0019 successfully modulates adhesion processes mediated by α4β7, α5β1, and αLβ2 integrins. |
| In vitro | In assays evaluating Jurkat cell adhesion, when bound to CS1-conjugated BSA, THI0019 enhanced cell binding in a dose-dependent manner, achieving an effective concentration (EC 50) of 1.7 μM. A more significant, 100-fold increase in Jurkat cell attachment was observed when using VCAM-1 as the ligand, with THI0019 demonstrating an EC 50 of 1.2 μM. Additionally, THI0019 increased EPC binding to VCAM-1 in a dose-dependent fashion (EC 50 of 3.7 μM). It also augmented cell rolling and spreading on VCAM-1 and enhanced cell migration toward SDF-1α[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | THI-0019 | THI 0019 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
-
-
-
CAS:1217341-48-4
$1520.00
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
|
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States