|
|
| | (S)-(+)-2-(METHOXYMETHYL)PYRROLIDINE Basic information |
| | (S)-(+)-2-(METHOXYMETHYL)PYRROLIDINE Chemical Properties |
| Boiling point | 62 °C40 mm Hg(lit.) | | density | 0.933 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.446 | | Fp | 114 °F | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | sol H2O, ether, dichloromethane. | | form | Liquid | | pka | 10.01±0.10(Predicted) | | color | Clear colorless to yellow | | Optical Rotation | [α]20/D +2.4°, c = 2 in benzene | | Sensitive | Air Sensitive | | BRN | 3587324 | | InChI | InChI=1S/C6H13NO/c1-8-5-6-3-2-4-7-6/h6-7H,2-5H2,1H3/t6-/m0/s1 | | InChIKey | CHPRFKYDQRKRRK-LURJTMIESA-N | | SMILES | N1CCC[C@H]1COC | | CAS DataBase Reference | 63126-47-6(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 10-36/37/38 | | Safety Statements | 26-36 | | RIDADR | UN 1993 3/PG 3 | | WGK Germany | 3 | | F | 3-9-34 | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29339900 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3 |
| | (S)-(+)-2-(METHOXYMETHYL)PYRROLIDINE Usage And Synthesis |
| Chemical Properties | clear colorless to yellow liquid | | Uses | (S)-(+)-2-(Methoxymethyl)pyrrolidine may be used to prepare planar chiral 2-phospha[3]ferrocenophanes. It may also be used as an organocatalyst in the cross-aldol reaction of dihydroxyacetone with p-nitrobenzaldehyde to form the corresponding polyol. SMP reacts with benzoylformic acid to form (S)-N-benzoylformyl-2-(methoxymethyl)-pyrrolidine. | | Definition | ChEBI: (S)-2-(methoxymethyl)pyrrolidine is a member of the class of pyrrolidines in which the only substituent is a methoxymethyl group at position 2 (the S-enantiomer0. It is a member of pyrrolidines and an ether. | | Application | (S)-(+)-2-(METHOXYMETHYL)PYRROLIDINE is used for chiral auxiliary; asymmetric syntheses with SMP enamines and SMP amides; asymmetric Birch
reductions; asymmetric Diels-Alder reactions. | | Synthesis | (S)-(+)-2-(methoxymethyl)pyrazolidine is an organic intermediate that can be prepared from (S)-proline reduction to prepare (S)-2-hydroxymethylpyrrolidine, then formylated and methylated to prepare (S)-(-)-2-(methoxymethyl)-1-pyrrolidinecarboxaldehyde, and finally deformylated to obtain (S)-(+)-2-(methoxymethyl)pyrazolidine.
| | storage | (S)-(+)-2-(METHOXYMETHYL)PYRROLIDINE stores at 0-4 °C under an argon atmosphere. |
| | (S)-(+)-2-(METHOXYMETHYL)PYRROLIDINE Preparation Products And Raw materials |
|