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Alinda Chemical Ltd.
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+7 (495) 672-17-08 |
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CAS:438618-32-7
Package:1mg Remarks:C20H30N2OS
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| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
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info@bocsci.com |
| Products Intro: |
Product Name:Glucagon Receptor Antagonist I
CAS:438618-32-7
Purity:>=99% Remarks:Reach out to us for more information about custom solutions.
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Glucagon Receptor Antagonist I manufacturers
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| | Glucagon Receptor Antagonist I Basic information |
| Product Name: | Glucagon Receptor Antagonist I | | Synonyms: | Glucagon Receptor Antagonist I;N-[3-cyano-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-2-ethylbutanamide;Butanamide, N-[3-cyano-6-(1,1-dimethylpropyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]-2-ethyl-;hGCGR Antagonist;Glucagon receptor antagonists-7;Glucagon receptor antagonist-7 | | CAS: | 438618-32-7 | | MF: | C20H30N2OS | | MW: | 346.53 | | EINECS: | | | Product Categories: | | | Mol File: | 438618-32-7.mol |  |
| | Glucagon Receptor Antagonist I Chemical Properties |
| Boiling point | 517.8±50.0 °C(Predicted) | | density | 1.07±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: soluble | | form | White crystalline solid. | | pka | 13.46±0.40(Predicted) |
| | Glucagon Receptor Antagonist I Usage And Synthesis |
| Description | Glucagon receptor antagonist I is a competitive antagonist of the glucagon receptor (GCGR; IC50 = 181 nM). It blocks glucagon-induced glycogenolysis in primary human hepatocytes and isolated liver. Glucagon receptor antagonist I, at 50 mg/kg, reduces the increase in glucose levels observed after intraperitoneal administration of glucagon in humanized mice. Glucagon receptor antagonist inactive control does not prevent glucagon-mediated actions. | | Uses | Glucagon receptor antagonist-7 (Compound 1) is an antagonist for hGCGR, that inhibits the binding of 125I-labeled glucagon to the human glucagon receptor (hGCGR) with IC50 of 181 nM. Glucagon receptor antagonist-7 activates glucagon-stimulated adenylyl cyclase with a KDB of 81 nM in CHO cell. Glucagon receptor antagonist-7 inhibits glucagon-mediated glycogenolysis in human hepatocytes, and lowers blood glucose levels[1]. | | References | [1] Qureshi SA, et al., A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects. Diabetes. 2004 Dec;53(12):3267-73. DOI:10.2337/diabetes.53.12.3267 |
| | Glucagon Receptor Antagonist I Preparation Products And Raw materials |
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