異長葉烯
| 中文名稱 | 異長葉烯 |
|---|---|
| 中文同義詞 | (-)-異長葉烯;異長葉烯;(2S)-1,3,4,5,6,7-六氫-1,1,5,5-四甲基-2H-2,4A-亞甲基萘;(1R)-2,2,7,7-四甲基三環(huán)[6.2.1.01.6]十一-5-烯;異長葉烯(甄準(zhǔn)不供應(yīng));異長(松)葉烯;化合物BIKININ;(-)-異氟龍酚 |
| 英文名稱 | Isolongifolene |
| 英文同義詞 | (-)-Isolongifolene >=98.0% (suM of enantioMers, GC);(-)-Isolongifoline;(2s)-1,3,4,5,6,7-hexahydro-1,1,5,5;2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-;C15 H24, 2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S)-;ISOLONGIFOLENE(SG);(2s)-2h-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-4a-methanonaphthalen;1,3,4,5,6,7-Hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene |
| CAS號(hào) | 1135-66-6 |
| 分子式 | C15H24 |
| 分子量 | 204.35 |
| EINECS號(hào) | 214-494-2 |
| 相關(guān)類別 | 香精香料;植物提取物;標(biāo)準(zhǔn)品;原料;香精與香料咨詢13026126800;有機(jī)化工原料;其他原料;化工原料;單體香料;有機(jī)原料 |
| Mol文件 | 1135-66-6.mol |
| 結(jié)構(gòu)式 |  |
異長葉烯 性質(zhì)
| 沸點(diǎn) | 255-256 °C |
|---|---|
| 密度 | 0.930 g/mL at 20 °C(lit.) |
| 蒸氣壓 | 5.49Pa at 25℃ |
| 折射率 | n |
| 閃點(diǎn) | 49°C |
| 儲(chǔ)存條件 | 2-8°C |
| 溶解度 | 二甲基亞砜：10 mg/mL（48.94 mM） |
| 形態(tài) | 液體 |
| 顏色 | 無色至淺黃 |
| 氣味 (Odor) | 木質(zhì)、塵土、琥珀香 |
| 香型 | woody |
| 旋光度 (Optical Rotation) | [α]20/D 138±2°, c = 1% in ethanol |
| 水溶解性 | 59.998μg/L at 25℃ |
| BRN | 2207559 |
| 化妝品成分功效 | 賦香 |
| InChI | 1S/C15H24/c1-13(2)8-5-6-12-14(3,4)11-7-9-15(12,13)10-11/h6,11H,5,7-10H2,1-4H3/t11-,15-/m0/s1 |
| InChIKey | CQUAYTJDLQBXCQ-NHYWBVRUSA-N |
| SMILES | CC1(C)CCC=C2C(C)(C)[C@H]3CC[C@@]12C3 |
| LogP | 5.77 at 25℃ |
| CAS 數(shù)據(jù)庫 | 1135-66-6(CAS DataBase Reference) |
| NIST化學(xué)物質(zhì)信息 | 2H-2,4a-methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2s)-(1135-66-6) |
| EPA化學(xué)物質(zhì)信息 | 2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S,4aR)- (1135-66-6) |
Isolongifolene ((-)-Isolongifolene) 是一種從 Murraya koenigii 中分離的三環(huán)倍半萜烯。Isolongifolene 通過調(diào)節(jié) P13K/AKT/GSK-3β 信號(hào)通路來減輕魚藤酮誘導(dǎo)的氧化應(yīng)激，線粒體功能障礙和細(xì)胞凋亡。Isolongifolene 具有抗氧化，抗炎，抗癌和神經(jīng)保護(hù)的特性。
Isolongifolene (0-50 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment significantly alleviates Rotenone-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner.
Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone-induced apoptosis in SH-SY5Y cells.
Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3β expression by Isolongifolene.
Cell Viability Assay
| Cell Line: | SH-SY5Y neuroblastoma cells |
| Concentration: | 0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 μM |
| Incubation Time: | 26 hours |
| Result: | Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells. |
Apoptosis Analysis
| Cell Line: | SH-SY5Y neuroblastoma cells |
| Concentration: | 10 μM |
| Incubation Time: | 26 hours |
| Result: | Attenuated Rotenone-induced apoptosis in SH-SY5Y cells. |
Western Blot Analysis
| Cell Line: | SH-SY5Y neuroblastoma cells |
| Concentration: | 10 μM |
| Incubation Time: | 26 hours |
| Result: | Attenuated rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β. |
用途
是制造具有木香香氣的合成香料異長葉烷酮和異長葉甲酸酯的主要原料安全信息
| 危險(xiǎn)類別碼 | 10 |
|---|---|
| 危險(xiǎn)品運(yùn)輸編號(hào) | UN 2319 3/PG 3 |
| WGK Germany | 3 |
| TSCA | TSCA listed |
| 危險(xiǎn)等級(jí) | 3.2 |
| 包裝類別 | III |
| 存儲(chǔ)類別 | 3- 易燃液體 |
| 危險(xiǎn)性類別 | 易燃液體 類別3 |
| 提供商 | 語言 |
|---|---|
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英文
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