異長(zhǎng)葉烯
| 中文名稱(chēng) | 異長(zhǎng)葉烯 |
|---|---|
| 中文同義詞 | (-)-異長(zhǎng)葉烯;異長(zhǎng)葉烯;(2S)-1,3,4,5,6,7-六氫-1,1,5,5-四甲基-2H-2,4A-亞甲基萘;(1R)-2,2,7,7-四甲基三環(huán)[6.2.1.01.6]十一-5-烯;異長(zhǎng)葉烯(甄準(zhǔn)不供應(yīng));異長(zhǎng)(松)葉烯;化合物BIKININ;(-)-異氟龍酚 |
| 英文名稱(chēng) | Isolongifolene |
| 英文同義詞 | (-)-Isolongifolene >=98.0% (suM of enantioMers, GC);(-)-Isolongifoline;(2s)-1,3,4,5,6,7-hexahydro-1,1,5,5;2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-;C15 H24, 2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S)-;ISOLONGIFOLENE(SG);(2s)-2h-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-4a-methanonaphthalen;1,3,4,5,6,7-Hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene |
| CAS號(hào) | 1135-66-6 |
| 分子式 | C15H24 |
| 分子量 | 204.35 |
| EINECS號(hào) | 214-494-2 |
| 相關(guān)類(lèi)別 | 香精香料;植物提取物;標(biāo)準(zhǔn)品;原料;香精與香料咨詢13026126800;有機(jī)化工原料;其他原料;化工原料;單體香料;有機(jī)原料 |
| Mol文件 | 1135-66-6.mol |
| 結(jié)構(gòu)式 |  |
異長(zhǎng)葉烯 性質(zhì)
| 沸點(diǎn) | 255-256 °C |
|---|---|
| 密度 | 0.930 g/mL at 20 °C(lit.) |
| 蒸氣壓 | 5.49Pa at 25℃ |
| 折射率 | n |
| 閃點(diǎn) | 49°C |
| 儲(chǔ)存條件 | 2-8°C |
| 溶解度 | 二甲基亞砜：10 mg/mL（48.94 mM） |
| 形態(tài) | 液體 |
| 顏色 | 無(wú)色至淺黃 |
| 氣味 (Odor) | 木質(zhì)、塵土、琥珀香 |
| 香型 | woody |
| 旋光度 (Optical Rotation) | [α]20/D 138±2°, c = 1% in ethanol |
| 水溶解性 | 59.998μg/L at 25℃ |
| BRN | 2207559 |
| 化妝品成分功效 | PERFUMING |
| InChI | 1S/C15H24/c1-13(2)8-5-6-12-14(3,4)11-7-9-15(12,13)10-11/h6,11H,5,7-10H2,1-4H3/t11-,15-/m0/s1 |
| InChIKey | CQUAYTJDLQBXCQ-NHYWBVRUSA-N |
| SMILES | CC1(C)CCC=C2C(C)(C)[C@H]3CC[C@@]12C3 |
| LogP | 5.77 at 25℃ |
| CAS 數(shù)據(jù)庫(kù) | 1135-66-6(CAS DataBase Reference) |
| NIST化學(xué)物質(zhì)信息 | 2H-2,4a-methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2s)-(1135-66-6) |
| EPA化學(xué)物質(zhì)信息 | 2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S,4aR)- (1135-66-6) |
Isolongifolene ((-)-Isolongifolene) 是一種從 Murraya koenigii 中分離的三環(huán)倍半萜烯。Isolongifolene 通過(guò)調(diào)節(jié) P13K/AKT/GSK-3β 信號(hào)通路來(lái)減輕魚(yú)藤酮誘導(dǎo)的氧化應(yīng)激，線粒體功能障礙和細(xì)胞凋亡。Isolongifolene 具有抗氧化，抗炎，抗癌和神經(jīng)保護(hù)的特性。
Isolongifolene (0-50 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment significantly alleviates Rotenone-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner.
Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone-induced apoptosis in SH-SY5Y cells.
Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3β expression by Isolongifolene.
Cell Viability Assay
| Cell Line: | SH-SY5Y neuroblastoma cells |
| Concentration: | 0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 μM |
| Incubation Time: | 26 hours |
| Result: | Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells. |
Apoptosis Analysis
| Cell Line: | SH-SY5Y neuroblastoma cells |
| Concentration: | 10 μM |
| Incubation Time: | 26 hours |
| Result: | Attenuated Rotenone-induced apoptosis in SH-SY5Y cells. |
Western Blot Analysis
| Cell Line: | SH-SY5Y neuroblastoma cells |
| Concentration: | 10 μM |
| Incubation Time: | 26 hours |
| Result: | Attenuated rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β. |
用途
是制造具有木香香氣的合成香料異長(zhǎng)葉烷酮和異長(zhǎng)葉甲酸酯的主要原料安全信息
| 危險(xiǎn)類(lèi)別碼 | 10 |
|---|---|
| 危險(xiǎn)品運(yùn)輸編號(hào) | UN 2319 3/PG 3 |
| WGK Germany | 3 |
| TSCA | TSCA listed |
| 危險(xiǎn)等級(jí) | 3.2 |
| 包裝類(lèi)別 | III |
| 存儲(chǔ)類(lèi)別 | 3- 易燃液體 |
| 危險(xiǎn)性類(lèi)別 | 易燃液體 類(lèi)別3 |
| 提供商 | 語(yǔ)言 |
|---|---|
|
英文
|