4-氯-DL-苯丙氨酸甲酯鹽酸鹽
| 中文名稱 | 4-氯-DL-苯丙氨酸甲酯鹽酸鹽 |
|---|---|
| 中文同義詞 | DL-4-氯苯丙氨酸甲酯鹽酸鹽;鹽酸-DL-4-氯苯丙氨酸甲酯;4-氯-DL-苯丙氨酸甲酯鹽酸鹽;對-氯-DL-苯基丙氨酸甲基酯鹽酸;對-氯-DL-苯基丙氨酸甲基酯鹽酸鹽;4-氯-DL-苯基丙氨酸甲酯鹽酸鹽;4-氯-DL-苯基丙氨酸甲酯;4-氯-DL-苯丙氨酸甲基酯鹽酸 |
| 英文名稱 | DL-4-Chlorophenylalanine methyl ester hydrochloride |
| 英文同義詞 | DL-P-CHLOROPHENYLALANINE METHYL ESTER*HY;4-Chloro-Dl-PhenylalanineMethylEster;4-CHLORO-DL-PHENYLALANINE METHYLESTER HCI;H-p-Chloro-DL-Phe-OMe;2-AMino-3-(4-chloro-phenyl)-propionic acid Methyl ester hydrochloride;(RS)-2-AMino-3-(4-chloro-phenyl)-propionic acid Methyl ester · HCl, H-4-Chloro-DL-Phe-OMe · HCl;(±)-4-Chlorophenylalanine methyl;4-Chloro-DL-phenylalanine methyl |
| CAS號 | 14173-40-1 |
| 分子式 | C10H13Cl2NO2 |
| 分子量 | 250.12 |
| EINECS號 | 238-024-0 |
| 相關(guān)類別 | 保護(hù)氨基酸;非天然氨基酸極其衍生物;化學(xué)生物學(xué);氨基酸衍生物;Phenylalanine [Phe, F];Unusual Amino Acids;Amino hydrochloride;Tryptophan Hydroxylase;Enzyme Inhibitors;Neurotransmitter Metabolism |
| Mol文件 | 14173-40-1.mol |
| 結(jié)構(gòu)式 |  |
4-氯-DL-苯丙氨酸甲酯鹽酸鹽 性質(zhì)
| 熔點(diǎn) | 186-189 °C(lit.) |
|---|---|
| 儲存條件 | -20°C |
| 溶解度 | 在水中溶解度為 100 mM，在 DMSO 中溶解度為 100 mM |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
| InChI | 1S/C10H12ClNO2.ClH/c1-14-10(13)9(12)6-7-2-4-8(11)5-3-7;/h2-5,9H,6,12H2,1H3;1H |
| InChIKey | GCBCWTWQAFLKJG-UHFFFAOYSA-N |
| SMILES | Cl.COC(=O)C(N)Cc1ccc(Cl)cc1 |
| CAS 數(shù)據(jù)庫 | 14173-40-1(CAS DataBase Reference) |
PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) 是一種可逆的色氨酸羥化酶 (tryptophan hydroxylase) 抑制劑，是 5-羥色胺 (5-HT) 合成抑制劑。PCPA methyl ester hydrochloride 可穿過血腦屏障，并降低 5-HT 的中樞利用率。
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serotonin
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Tryptophan Hydroxylase
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PCPA methyl ester hydrochloride (250-500 mg/kg; oral administration; daily; for 8 weeks) treatment significantly decreases serotonin levels in both hippocampus and cortex.
In C57BL/6 elite male mice, 5-HT levels decreased by 85% and 55% in the hippocampus of mice treated with oral or ip PCPA methyl ester hydrochloride, respectively, whereas in the prefrontal cortex, 5-HT levels decreased by 65% (oral) and 50% (ip).
| Animal Model: | C57BL/6 elite male mice (3 months old) |
| Dosage: | 500 mg/kg per day for the first 2 days and 250 mg/kg for the rest of the treatment |
| Administration: | Oral administration; daily; for 8 weeks |
| Result: | Serotonin levels were significantly decreased in both hippocampus and cortex. |
用途
色氨酸羥化酶抑制劑?？缭窖X屏障優(yōu)于P-氯苯丙氨酸。安全信息
| 安全說明 | 24/25 |
|---|---|
| WGK Germany | 3 |
| RTECS號 | AY4452100 |
| 海關(guān)編碼 | 29224999 |
| 存儲類別 | 11 - 可燃固體 |
| 提供商 | 語言 |
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英文
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英文
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| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-101456 | 4-氯-DL-苯丙氨酸甲酯鹽酸鹽 PCPA methyl ester hydrochloride | 14173-40-1 | 1 g | 800元 |
| 2026/06/05 | HY-101456 | 4-氯-DL-苯丙氨酸甲酯鹽酸鹽 PCPA methyl ester hydrochloride | 14173-40-1 | 10 mM * 1 mLin DMSO | 880元 |