14173-40-1
中文名稱
4-氯-DL-苯丙氨酸甲酯鹽酸鹽
英文名稱
DL-4-Chlorophenylalanine methyl ester hydrochloride
CAS
14173-40-1
EINECS 編號
238-024-0
分子式
C10H13Cl2NO2
MDL 編號
MFCD00012530
分子量
250.12
MOL 文件
14173-40-1.mol
更新日期
2024/12/13 16:55:33
14173-40-1 結(jié)構(gòu)式
基本信息
中文別名
4-氯-DL-苯丙氨酸甲酯鹽酸鹽DL-4-氯苯丙氨酸甲酯鹽酸鹽
鹽酸-DL-4-氯苯丙氨酸甲酯
英文別名
4-CHLORO-DL-PHENYLALANINE METHYL ESTER HCL4-CHLORO-DL-PHENYLALANINE METHYL ESTER HYDROCHLORIDE
4-CHLORO-DL-PHE-OME HCL
DL-4-CHLOROPHENYLALANINE METHYL ESTER HYDROCHLORIDE
DL-P-CHLOROPHENYLALANINE METHYL ESTER HYDROCHLORIDE
H-DL-PHE(4-CL)-OME HCL
H-P-CHLORO-DL-PHE-OME HCL
Methyl 4-chloro-3-phenyl-DL-alaninate hydrochloride
P-CHLORO-DL-PHENYLALANINE HCL
P-CHLORO-DL-PHENYLALANINE METHYL ESTER HYDROCHLORIDE
TIMTEC-BB SBB003149
3-(p-chlorophenyl)-,methylester,hydrochloride,dl-alanin
dl-3-(p-chlorophenyl)alaninemethylesterhydrochloride
dl-pcpamethylesterhydrochloride
dl-phenylalanine,4-chloro-,methylester,hydrochloride
DL-P-CHLOROPHENYLALANINE METHYL ESTER*HY
4-Chloro-Dl-PhenylalanineMethylEster
4-Chloro-DL-Phe-OMe•
4-CHLORO-DL-PHENYLALANINE METHYLESTER HCI
(±)-4-Chlorophenylalanine methyl
所屬類別
生物化工：苯丙氨酸類衍生物物理化學(xué)性質(zhì)
熔點186-189 °C(lit.)
熔點186-189 °C(lit.)
儲存條件−20°C
儲存條件-20°C
溶解度Soluble to 100 mM in water and to 100 mM in DMSO
形態(tài)固體
顏色White to off-white
InChI1S/C10H12ClNO2.ClH/c1-14-10(13)9(12)6-7-2-4-8(11)5-3-7;/h2-5,9H,6,12H2,1H3;1H
InChIKeyGCBCWTWQAFLKJG-UHFFFAOYSA-N
SMILESCl.COC(=O)C(N)Cc1ccc(Cl)cc1
CAS 數(shù)據(jù)庫14173-40-1(CAS DataBase Reference)
安全數(shù)據(jù)
4-氯-DL-苯丙氨酸甲酯鹽酸鹽價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/12/22 | HY-101456 | 4-氯-DL-苯丙氨酸甲酯鹽酸鹽 PCPA methyl ester hydrochloride | 14173-40-1 | 1 g | 800元 |
| 2025/12/22 | HY-101456 | 4-氯-DL-苯丙氨酸甲酯鹽酸鹽 PCPA methyl ester hydrochloride | 14173-40-1 | 10 mM * 1 mLin DMSO | 880元 |
| 2025/12/22 | HY-101456 | 4-氯-DL-苯丙氨酸甲酯鹽酸鹽 PCPA methyl ester hydrochloride | 14173-40-1 | 5 g | 2000元 |
常見問題列表
生物活性
PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) 是一種可逆的色氨酸羥化酶 (tryptophan hydroxylase) 抑制劑，是 5-羥色胺 (5-HT) 合成抑制劑。PCPA methyl ester hydrochloride 可穿過血腦屏障，并降低 5-HT 的中樞利用率。靶點
|
serotonin
|
Tryptophan Hydroxylase
|
體內(nèi)研究
PCPA methyl ester hydrochloride (250-500 mg/kg; oral administration; daily; for 8 weeks) treatment significantly decreases serotonin levels in both hippocampus and cortex.
In C57BL/6 elite male mice, 5-HT levels decreased by 85% and 55% in the hippocampus of mice treated with oral or ip PCPA methyl ester hydrochloride, respectively, whereas in the prefrontal cortex, 5-HT levels decreased by 65% (oral) and 50% (ip).
| Animal Model: | C57BL/6 elite male mice (3 months old) |
| Dosage: | 500 mg/kg per day for the first 2 days and 250 mg/kg for the rest of the treatment |
| Administration: | Oral administration; daily; for 8 weeks |
| Result: | Serotonin levels were significantly decreased in both hippocampus and cortex. |