N-乙酰-L-4-羥基脯氨酸
| 中文名稱 | N-乙酰-L-4-羥基脯氨酸 |
|---|---|
| 中文同義詞 | N-乙酰-L-羥脯氨酸;奧沙西羅;酰羥氫吡咯酸;N-乙酰-4-羥基-L-脯氨酸;1-乙?；?4-羥基吡咯烷羧酸;4-羥基-N-乙?；彼?反式-1-乙酰基-4-羥基-L-脯氨酸;N-乙酰-4-羥基脯氨酸 |
| 英文名稱 | Oxaceprol |
| 英文同義詞 | N-ACETYLHYDROXY-L-PROLINE;N-ALPHA-ACETYL-TRANS-4-HYROXY-L-PYROLLIDINE;N-ALPHA-ACETYL-L-4-TRANS-HYDROXYPROLINE;N-ALPHA-ACETYL-L-HYROXYPROLINE;(-)-1-Acetyl-4β-hydroxy-L-proline;(4R)-1-Acetyl-4-hydroxy-L-proline;trans-1-Acetyl-4-hydroxy-L-proline 99%;trans-1-Acetyl-4-hydroxy-L-proline, >=98% |
| CAS號 | 33996-33-7 |
| 分子式 | C7H11NO4 |
| 分子量 | 173.17 |
| EINECS號 | 251-780-6 |
| 相關(guān)類別 | 生化試劑;中間體;佐芬普利鈣相關(guān)中間體;氨基酸;氨基酸衍生物;醫(yī)藥中間體;保護(hù)氨基酸;PYRROLE;API intermediates;Amino Acids;胺基酸;Hydroxyproline [Hyp];Peptide Synthesis;Proline Derivatives;Unnatural Amino Acid Derivatives;非天然氨基酸;合成;氨基酸類 |
| Mol文件 | 33996-33-7.mol |
| 結(jié)構(gòu)式 |  |
N-乙酰-L-4-羥基脯氨酸 性質(zhì)
| 熔點(diǎn) | 132-133 °C (dec.)(lit.) |
|---|---|
| 比旋光度 | -119 º (c=4 in H2O) |
| 沸點(diǎn) | 303.8°C (rough estimate) |
| 密度 | 1.3346 (rough estimate) |
| 蒸氣壓 | 0Pa at 20℃ |
| 折射率 | 1.4490 (estimate) |
| 儲存條件 | Sealed in dry,2-8°C |
| 溶解度 | 二甲基亞砜：≥32mg/mL（184.79mM） |
| 形態(tài) | 結(jié)晶粉末 |
| 酸度系數(shù)(pKa) | 3.48±0.40(Predicted) |
| 顏色 | 白色 |
| 旋光度 (Optical Rotation) | [α]20/D 119°, c = 4 in H2O |
| Merck | 14,6903 |
| BRN | 84043 |
| 主要應(yīng)用 | 肽合成 |
| 化妝品成分功效 | 保濕劑 皮膚保護(hù) 皮膚調(diào)理 皮膚調(diào)理 - 潤膚劑 護(hù)發(fā)素 |
| InChI | 1S/C7H11NO4/c1-4(9)8-3-5(10)2-6(8)7(11)12/h5-6,10H,2-3H2,1H3,(H,11,12)/t5-,6+/m1/s1 |
| InChIKey | BAPRUDZDYCKSOQ-RITPCOANSA-N |
| SMILES | CC(=O)N1C[C@H](O)C[C@H]1C(O)=O |
| LogP | -1.51 at 20℃ |
| CAS 數(shù)據(jù)庫 | 33996-33-7(CAS DataBase Reference) |
| EPA化學(xué)物質(zhì)信息 | L-Proline, 1-acetyl-4-hydroxy-, (4R)- (33996-33-7) |
Oxaceprol (N-acetyl-L-hydroxyproline) 是一種抗炎性藥物，用于治療骨關(guān)節(jié)炎。
Oxaceprol, at 6 mg/kg/day for 7 days, significantly reduces both the surface area and wet weight of cotton pellet granulomas, being slightly less effective than indomethacin, 3 mg/kg.
Oxaceprol (6–54 mg/kg/day) given therapeutically had no effect on the primary paw oedema response, but inhibits secondary lesions in the ears and tail.
Oxaceprol does not inhibit the synthesis of prostaglandins in vitro, but markedly inhibits neutrophil infiltration into the joints of rats with adjuvant arthritis.
| Animal Model: | Male Sprague-Dawley rats. |
| Dosage: | 18, 50 or 150 mg/kg. |
| Administration: | Gavage daily for 15 days. |
| Result: | Produced comparable inhibition of hyperalgesia to that produced by indomethacin. |
安全信息
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| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/07/06 | B23767 | N-乙酰-4-羥基脯氨酸, 99% N-Acetyl-trans-4-hydroxy-L-proline, 99% | 33996-33-7 | 10g | 1059元 |
| 2026/07/06 | S3997 | N-乙酰-L-4-羥基脯氨酸 Oxaceprol | 33996-33-7 | 25mg | 794.69元 |