AZ32
| 中文名稱 | AZ32 |
|---|---|
| 中文同義詞 | N-甲基-4-(6-苯基咪唑[1,2-A]吡嗪-3-)苯甲酰胺;化合物AZ32;N-甲基-4-(6-苯基咪唑并[1,2-A]吡嗪-3-基)苯甲酰胺;化合物AZ32,10 MM DMSO 溶液;AZ32 ,S8729;AZ32【CAS:2288709-96-4】【規(guī)格:1ml】【純度:10mM in DMSO】;AZ32【CAS：2288709-96-4】【規(guī)格：1ml】【純度：10mM in DMSO】 |
| 英文名稱 | AZ32 |
| 英文同義詞 | Benzamide, N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)-;N-Methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide;AZ32;Ataxia telangiectasia mutated,ATM and RAD3 related,inhibit,Inhibitor,AZ 32,AZ-32,AZ32,ATM/ATR;AZ32, 10 mM in DMSO;AZ32 ，S8729 |
| CAS號 | 2288709-96-4 |
| 分子式 | C20H16N4O |
| 分子量 | 328.37 |
| EINECS號 | |
| 相關(guān)類別 | 標(biāo)準(zhǔn)品 |
| Mol文件 | 2288709-96-4.mol |
| 結(jié)構(gòu)式 |  |
AZ32 性質(zhì)
| 密度 | 1.25±0.1 g/cm3(Predicted) |
|---|---|
| 儲存條件 | Store at -20°C |
| 溶解度 | 二甲基亞砜：150mg/mL |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 14.63±0.46(Predicted) |
| 顏色 | 白色至米白色 |
| InChI | 1S/C20H16N4O/c1-21-20(25)16-9-7-15(8-10-16)18-11-23-19-12-22-17(13-24(18)19)14-5-3-2-4-6-14/h2-13H,1H3,(H,21,25) |
| InChIKey | LCRTUEXVVKVKBD-UHFFFAOYSA-N |
| SMILES | [n]21c(ncc2c4ccc(cc4)C(=O)NC)C=NC(=C1)c3ccccc3 |
|
ATM 6.2 nM (IC 50 ) |
ATM 0.31 μM (IC 50 , in cell) |
AZ32 is a next-generation blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro.
AZ32, with enhanced BBB penetration, is highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse. Following a single oral dose of AZ32 (200 mg/kg) in mice, the free-brain concentrations of AZ32 are in excess of the cellular IC 50 for approximately 22 hours.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲類別 | 11 - 可燃固體 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/07/06 | S8729 | AZ32 AZ32 | 2288709-96-4 | 5mg | 1204.59元 |
| 2026/07/06 | S8729 | AZ32 | 2288709-96-4 | 10mM (1mL in DMSO) | 1367.73元 |