1,3-Propanediol, 2-amino-2-[2-[4'-(2-propyl-4-oxazolyl)[1,1'-biphenyl]-4-yl]ethyl]-

1,3-Propanediol, 2-amino-2-[2-[4'-(2-propyl-4-oxazolyl)[1,1'-biphenyl]-4-yl]ethyl]- Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:IMMH001
CAS:1418093-75-0
Package:50mg;1980USD|100mg;2500USD|25mg;1520USD
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:IMMH001
CAS:1418093-75-0
Package:1removed

1,3-Propanediol, 2-amino-2-[2-[4'-(2-propyl-4-oxazolyl)[1,1'-biphenyl]-4-yl]ethyl]- manufacturers

  • IMMH001
  • IMMH001 pictures
  • $928.00
  • 2026-06-15
  • CAS:1418093-75-0
  • Purity: 97.81%
  • Supply Ability: 10g
1,3-Propanediol, 2-amino-2-[2-[4'-(2-propyl-4-oxazolyl)[1,1'-biphenyl]-4-yl]ethyl]- Basic information
Product Name:1,3-Propanediol, 2-amino-2-[2-[4'-(2-propyl-4-oxazolyl)[1,1'-biphenyl]-4-yl]ethyl]-
Synonyms:1,3-Propanediol, 2-amino-2-[2-[4'-(2-propyl-4-oxazolyl)[1,1'-biphenyl]-4-yl]ethyl]-;IMMH001
CAS:1418093-75-0
MF:C23H28N2O3
MW:380.48
EINECS:
Product Categories:
Mol File:1418093-75-0.mol
1,3-Propanediol, 2-amino-2-[2-[4'-(2-propyl-4-oxazolyl)[1,1'-biphenyl]-4-yl]ethyl]- Structure
1,3-Propanediol, 2-amino-2-[2-[4'-(2-propyl-4-oxazolyl)[1,1'-biphenyl]-4-yl]ethyl]- Chemical Properties
Boiling point 618.6±55.0 °C(Predicted)
density 1.165±0.06 g/cm3(Predicted)
pka12.19±0.20(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
1,3-Propanediol, 2-amino-2-[2-[4'-(2-propyl-4-oxazolyl)[1,1'-biphenyl]-4-yl]ethyl]- Usage And Synthesis
UsesIMMH001, also called SYL930, is an orally active, potent and selective S1P1 (sphingosine-1-phosphate receptor 1) agonist. IMMH001 decreased levels of both chemokines and proinflammatory cytokines, including IL-1β, IL-5, IL-18, IP10, CCL3, and CCL5. IMMH001 can be used for rheumatoid arthritis (RA) research[1][2].
in vivo

IMMH001 is converted to the active form, its monophosphate ester (S)-IMMH001-P, by sphingosine kinase 1 (SphK1) and sphingosine kinase 2 (SphK2) in vivo[1].
IMMH001 suppresses both Th1 cell (IL-1β, IL-18, and IP10) and Th2 cell (IL-5)-mediated disease reactions in damaged joints[2].
IMMH001 (0.3-2.4 mg/kg, Orally; twice a week, for 28 days, AA rats; for 30 days, CIA rats) relieves the damage of AA (adjuvant-induced arthritis) and CIA (collagen-induced arthritis) rats’ joints[2].

IC 50S1PR1
References[1] Xiao Q, et al. Design and synthesis of analogues of the sphingosine-1-phosphate receptor 1 agonist IMMH001 with improved phosphorylation rate in human blood. Bioorg Med Chem. 2020 Nov 1;28(21):115722. DOI:10.1016/j.bmc.2020.115722
[2] Jin J, et al. Sphingosine-1-Phosphate Receptor Subtype 1 (S1P1) Modulator IMMH001 Regulates Adjuvant- and Collagen-Induced Arthritis. Front Pharmacol. 2019 Sep 19;10:1085. DOI:10.3389/fphar.2019.01085
1,3-Propanediol, 2-amino-2-[2-[4'-(2-propyl-4-oxazolyl)[1,1'-biphenyl]-4-yl]ethyl]- Preparation Products And Raw materials
Tag:1,3-Propanediol, 2-amino-2-[2-[4'-(2-propyl-4-oxazolyl)[1,1'-biphenyl]-4-yl]ethyl]-(1418093-75-0) Related Product Information