Product Details
| Product Name:
IMMH001 |
CAS No.:
1418093-75-0 |
| Purity:
97.81% |
Supply Ability:
10g |
| Release date:
2026/06/15 |
Product Introduction
Bioactivity
| Name | IMMH001 |
| Description | IMMH001, also known as SYL930, is an orally active compound that exhibits potent selectivity as an agonist for the S1P1 receptor, which is the sphingosine-1-phosphate receptor 1. This compound effectively reduces the levels of various chemokines and proinflammatory cytokines, such as IL-1β, IL-5, IL-18, IP10, CCL3, and CCL5. IMMH001 finds utility in research focused on rheumatoid arthritis (RA) [1] [2]. |
| In vivo | IMMH001 is metabolized into its active monophosphate ester form, (S)-IMMH001-P, by the action of sphingosine kinase 1 (SphK1) and sphingosine kinase 2 (SphK2) in vivo [1]. This compound effectively diminishes disease manifestations mediated by both Th1 (IL-1β, IL-18, and IP10) and Th2 (IL-5) cells in inflamed joints [2]. Administered orally at doses ranging from 0.3 to 2.4 mg/kg twice weekly for durations of 28 days in adjuvant-induced arthritis (AA) rats and 30 days in collagen-induced arthritis (CIA) rats, IMMH001 significantly alleviates joint damage in these models [2]. |
| Storage | Keep away from direct sunlight,Keep away from moisture,Store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (210.26 mM), Sonication is recommended.
|
| Inhibitors Related | Fingolimod hydrochloride | SLP9101555 | BMS-960 | LX-2931 | Sphingosine-1-phosphate | CYM50374 | ASP-4058 | Siponimod | MP-A08 | Ozanimod | W140 HBr | Etrasimod |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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