- 2-Chlorobenzoxazole
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-
2025-12-01
- CAS:615-18-9
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10000KGS
- 2-Chlorobenzoxazole
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-
2022-02-22
- CAS:615-18-9
- Min. Order: 1KG
- Purity: 97.5%
- Supply Ability: 100 tons
- 2-Chlorobenzoxazole
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- $8.00
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2019-07-06
- CAS: 615-18-9
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10tons
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| | 2-Chlorobenzoxazole Basic information |
| | 2-Chlorobenzoxazole Chemical Properties |
| Melting point | 7 °C(lit.) | | Boiling point | 201-202 °C(lit.) | | density | 1.345 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.566(lit.) | | Fp | 185 °F | | storage temp. | Inert atmosphere,2-8°C | | form | Powder | | pka | 0.62±0.10(Predicted) | | color | White | | Water Solubility | Not miscible in water. | | BRN | 115982 | | InChI | InChI=1S/C7H4ClNO/c8-7-9-5-3-1-2-4-6(5)10-7/h1-4H | | InChIKey | BBVQDWDBTWSGHQ-UHFFFAOYSA-N | | SMILES | O1C2=CC=CC=C2N=C1Cl | | CAS DataBase Reference | 615-18-9(CAS DataBase Reference) | | NIST Chemistry Reference | Benzoxazole, 2-chloro-(615-18-9) | | EPA Substance Registry System | Benzoxazole, 2-chloro- (615-18-9) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-36/37/38 | | Safety Statements | 26-36/37/39-37/39-36 | | WGK Germany | 3 | | RTECS | DM4680000 | | F | 10 | | TSCA | TSCA listed | | HS Code | 29349990 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-Chlorobenzoxazole Usage And Synthesis |
| Chemical Properties | clear yellow liquid | | Uses | 2-Chlorobenzoxazole was used in the synthesis of 2-(2-naphthylamino)benzoxazole via reaction with 2-amino-1-naphthalenesulfonic acid. | | Synthesis | General procedure for the synthesis of 2-chlorobenzoxazole from 2-mercaptobenzoxazole: 2-mercaptobenzoxazole (10 mmol, 1.51 g) was suspended in SOCl2 (50 mL), and a few drops of DMF were added as catalyst. The reaction mixture was heated to reflux for 5 hours. After completion of the reaction, the solvent was removed by evaporation. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/EtOAc, 10:1) to afford the target compound as a colorless oil in 69.7% yield. | | Purification Methods | Purify it by fractional distillation, preferably in a vacuum. [Siedel J Prakt Chem 42 456 1890, Katz J Am Chem Soc 75 712 1953, Meyer & Sigel J Org Chem 42 2769 1977, Beilstein 27 H 43, 27 II 17.] | | References | [1] Patent: US4517370, 1985, A
[2] Heteroatom Chemistry, 2001, vol. 12, # 3, p. 151 - 155
[3] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 21, p. 5374 - 5379
[4] Patent: CN108794421, 2018, A. Location in patent: Paragraph 0028-0030
[5] Tetrahedron, 1986, vol. 42, # 14, p. 3905 - 3912 |
| | 2-Chlorobenzoxazole Preparation Products And Raw materials |
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