- Licochalcone D
-
- $97.00
-
2026-06-02
- CAS:144506-15-0
- Purity: 99.90%
- Supply Ability: 10g
- Licochalcone D
-
-
2024-04-12
- CAS:144506-15-0
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 2000ton
- Licochalcone D
-
-
2023-02-24
- CAS:144506-15-0
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
|
| | 2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)- Basic information |
| Product Name: | 2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)- | | Synonyms: | 2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)-;(E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]prop-2-en-1-one;2-Propen-1-one, 3-(3,4-dihydroxy-2-methoxyphenyl)-1-[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-, (2E)-;Licochalcone D,Apoptosis,A375,anti-cancer,antioxidant,Reactive Oxygen Species,Nuclear factor-κB,NF-κB p65,NF-κB,Nuclear factor-kappaB,Inhibitor,anti-inflammatory,inhibit;Licochalcone D, 10 mM in DMSO;(E)-3-(3,4-Dihydroxy-2-methoxyphenyl)-1-(4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl)prop-2-en-1-one | | CAS: | 144506-15-0 | | MF: | C21H22O5 | | MW: | 354.4 | | EINECS: | | | Product Categories: | | | Mol File: | 144506-15-0.mol | ![2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)- Structure](CAS/GIF/144506-15-0.gif) |
| | 2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)- Chemical Properties |
| Melting point | 113° | | Boiling point | 590.0±50.0 °C(Predicted) | | density | 1.244±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO: 125 mg/mL (352.71 mM) | | form | Solid | | pka | 8.38±0.20(Predicted) | | color | Light yellow to yellow | | InChI | InChI=1S/C21H22O5/c1-13(2)4-5-15-12-16(8-10-18(15)23)17(22)9-6-14-7-11-19(24)20(25)21(14)26-3/h4,6-12,23-25H,5H2,1-3H3/b9-6+ | | InChIKey | RETRVWFVEFCGOK-RMKNXTFCSA-N | | SMILES | C(C1=CC=C(O)C(C/C=C(/C)\C)=C1)(=O)/C=C/C1=CC=C(O)C(O)=C1OC |
| | 2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)- Usage And Synthesis |
| Chemical Properties | White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the rhizome of Glycyrrhiza uralensis Fisch. | | Uses | Licochalcone D, a flavonoid compound mainly existing in the root of Glycyrrhiza uralensis, is a potent and orally active inhibitor of NF-kappaB (NF-κB) p65. Licochalcone D possesses antioxidant, anti-inflammatory, anti-cancer properties[1][2]. | | in vivo | Licochalcone D (25 and 50 mg/kg; i.g.; daily for a week) inhibits the tumor growth in a mouse xenograft model of murine melanoma B16F0 cells[2]. | Animal Model: | C57BL/6 mice, B16F0 tumor model[2] | | Dosage: | 25 and 50 mg/kg | | Administration: | Intragastric administration, daily for a week | | Result: | Obviously lowered the tumor growth rates, the tumor growth inhibition rates were calculated to be 32.0 and 54.1% at 25 and 50 mg/kg, respectively. |
| | IC 50 | p65 | | References | [1] Furusawa J, et al. Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway. Int Immunopharmacol. 2009 Apr;9(4):499-507. DOI:10.1016/j.intimp.2009.01.031
[2] Si L, et al. Licochalcone D induces apoptosis and inhibits migration and invasion in human melanoma A375 cells. Oncol Rep. 2018 May;39(5):2160-2170. DOI:10.3892/or.2018.6329 |
| | 2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)- Preparation Products And Raw materials |
|