BMT-145027

BMT-145027 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:BMT-145027
CAS:2018282-44-3
Purity:99.5% Package:1mg;38USD|5mg;93USD|10mg;157USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: BOC Sciences
Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Products Intro: Product Name:BMT-145027
CAS:2018282-44-3
Remarks:Please reach out to us for more information about custom solutions.
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:BMT-145027
CAS:2018282-44-3
Purity:99.5% Package:1mg;38USD|5mg;93USD|10mg;157USD
Company Name: Aladdin Scientific
Tel:
Email: tp@aladdinsci.com
Products Intro: Product Name:BMT-145027
CAS:2018282-44-3
Purity:98% Package:$240.9/5mg;$410.9/10mg;$1200.9/50mg;Bulk package Remarks:98%
Company Name: Shanghai Boyle Chemical Co., Ltd.  
Tel:
Email: sales@boylechem.com
Products Intro: Product Name:BMT-145027

BMT-145027 manufacturers

  • BMT-145027
  • BMT-145027 pictures
  • $34.00
  • 2026-06-08
  • CAS:2018282-44-3
  • Purity: 99.62%
  • Supply Ability: 10g
  • BMT-145027
  • BMT-145027 pictures
  • $34.00
  • 2026-06-08
  • CAS:2018282-44-3
  • Purity: 99.62%
  • Supply Ability: 10g
BMT-145027 Basic information
Product Name:BMT-145027
Synonyms:BMT-145027;1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile, 3-[4-chloro-3-(trifluoromethyl)phenyl]-4-cyclopropyl-6-phenyl-;3-[4-chloro-3-(trifluoromethyl)phenyl]-4-cyclopropyl-6-phenyl-2H-pyrazolo[3,4-b]pyridine-5-carbonitrile;BMT145027;BMT 145027;Inhibitor,mGluR,inhibit,BMT-145027,BMT145027,BMT 145027,Metabotropic glutamate receptors
CAS:2018282-44-3
MF:C23H14ClF3N4
MW:438.83
EINECS:
Product Categories:
Mol File:2018282-44-3.mol
BMT-145027 Structure
BMT-145027 Chemical Properties
Boiling point 653.2±55.0 °C(Predicted)
density 1.51±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 2.4 mg/mL (5.47 mM)
pka7.40±0.40(Predicted)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
BMT-145027 Usage And Synthesis
UsesBMT-145027 is an mGluR5 positive allosteric modulator without inherent agonist activity, exhibits an EC50 of 47 nM.
in vivo

Drug-treated and control mice are shown two identical objects. After a 24-h natural forgetting period, the mice are reintroduced to a familiar object while simultaneously presented with a novel object. Since mice spend more time exploring unfamiliar objects, improved memory is measured as time spent exploring the novel object. BMT-145027 leads to a significant increase in time spent with the novel object when dosed at 30 mg/kg, with an apparent trend in novel object preference at 10 mg/kg. Satellite animals indicates a total plasma concentration of 2800 nM at 30 mg/kg[1].

IC 50mGluR5: 47 nM (EC50)
References[1] Hill MD, et al. Development of 1H-Pyrazolo[3,4-b]pyridines as Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators. ACS Med Chem Lett. 2016 Oct 3;7(12):1082-1086. DOI:10.1021/acsmedchemlett.6b00292
BMT-145027 Preparation Products And Raw materials
Tag:BMT-145027(2018282-44-3) Related Product Information