- Boc-Thr-OMe
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2026-07-23
- CAS:79479-07-5
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T
- Boc-Thr-OMe
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- $1.00
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2020-01-06
- CAS:79479-07-5
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 100KG
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| | Methyl N-(tert-butoxycarbonyl)-L-threoninate Basic information |
| Product Name: | Methyl N-(tert-butoxycarbonyl)-L-threoninate | | Synonyms: | N-(TERT-BUTOXYCARBONYL)-L-THREONINE MET&;N-BOC-L-threonine methylester;(2S,3R)-methyl 2-(tert-butoxycarbonylamino)-3-hydroxybutanoate;Boc-L-Thr-OMe;Boc-L-threonine methyl ester≥ 98% (HPLC);(2S, 3S)-2-Tert-butoxycarbonylaMino-3-hydroxy-butyric acid Methyl ester Boc-Thr-OMe;methyl (2S,3R)-2-{[(tert-butoxy)carbonyl]amino}-3-hydroxybutanoate;Methyl N-(tert-butoxycarbonyl)-L-threoninate | | CAS: | 79479-07-5 | | MF: | C10H19NO5 | | MW: | 233.26 | | EINECS: | | | Product Categories: | Threonine;Amino Acid Derivatives;Peptide Synthesis | | Mol File: | 79479-07-5.mol |  |
| | Methyl N-(tert-butoxycarbonyl)-L-threoninate Chemical Properties |
| Boiling point | 206 °C(lit.) | | density | 1.123±0.06 g/cm3(Predicted) | | refractive index | n20/D 1.45(lit.) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform (Sparingly), Dichloromethane (Sparingly), DMF (Sparingly) | | pka | 11.00±0.46(Predicted) | | form | Viscous Liquid | | color | Yellow | | Water Solubility | Slightly soluble in water. | | Major Application | peptide synthesis | | InChI | 1S/C10H19NO5/c1-6(12)7(8(13)15-5)11-9(14)16-10(2,3)4/h6-7,12H,1-5H3,(H,11,14)/t6-,7+/m1/s1 | | InChIKey | MZMWAPNVRMDIPS-RQJHMYQMSA-N | | SMILES | COC(=O)[C@@H](NC(=O)OC(C)(C)C)[C@@H](C)O |
| WGK Germany | 3 | | HS Code | 29241990 | | Storage Class | 10 - Combustible liquids |
| | Methyl N-(tert-butoxycarbonyl)-L-threoninate Usage And Synthesis |
| Chemical Properties | Light yellow transparent oil | | Uses | N-Boc-L-threonine methyl ester is used as pharmaceutical intermediates and chemical intermediate. | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | The general procedure for the synthesis of Boc-D-alanine methyl ester from (2S,3R)-2-((tert-butoxycarbonyl)amino)-3-hydroxybutanoic acid and dimethyl sulfate was as follows:
1) Synthesis of N-Boc-L-threonine methyl ester: Potassium carbonate (34.7 g, 250 mmol) and dimethyl sulfate (29.3 g, 232 mmol) were sequentially added to a solution of N-Boc-L-threonine (50.0 g, 213 mmol) in acetone (250 mL). The reaction mixture was heated to reflux for 1 h and subsequently cooled to room temperature in air. Insoluble solids were removed by filtration and the filtrate was concentrated under reduced pressure to remove the solvent to afford N-tert-butoxycarbonyl-L-threonine methyl ester as a colorless oil (54.6 g, 100% yield). The product was characterized by 1H-NMR (300 MHz, DMSO-d6): δ 1.26 (3H, d, J = 6.42 Hz), 1.46 (9H, s), 2.02 (1H, d, J = 5.14 Hz), 3.78 (3H, s), 4.28 (1H, m), 5.29 (1H, m). Mass spectra (FAB) showed molecular ion peak m/z: 234 ([M + H]+). | | References | [1] Patent: EP1621537, 2006, A1. Location in patent: Page/Page column 25
[2] Patent: CN108003048, 2018, A. Location in patent: Paragraph 0013 |
| | Methyl N-(tert-butoxycarbonyl)-L-threoninate Preparation Products And Raw materials |
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