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鹽酸法倔唑

鹽酸法倔唑

中文名稱鹽酸法倔唑
中文同義詞法倔唑鹽酸鹽;4-(5,6,7,8-四氫咪唑并[1,5-A]吡啶-5-基)苯腈鹽酸鹽;鹽酸法卓唑;化合物:Fadrozole (hydrochloride);化合物:Fadrozole (hydrochloride)
英文名稱FADROZOLE HYDROCHLORIDE
英文同義詞FADROZOLE HYDROCHLORIDE;CGS-16949A;Fadrazole;D02451;Fadrozole hydrochloride (usan);4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile hydrochloride;4-(5,6,7,8-TETRAHYDROIMIDAZO[1,5-A]PYRIDIN-5-YL)BENZONITRILE(WXC09920);Fadrozole HCl
CAS號(hào)102676-31-3
分子式C14H13N3.ClH
分子量259.739
EINECS號(hào)
相關(guān)類別化學(xué)連接
Mol文件102676-31-3.mol
結(jié)構(gòu)式鹽酸法倔唑 結(jié)構(gòu)式

鹽酸法倔唑 性質(zhì)

熔點(diǎn)231-233℃
儲(chǔ)存條件room temp
溶解度二甲基亞砜:>20mg/mL
形態(tài)粉末
顏色淡米色至淡黃色
穩(wěn)定性吸濕性
InChI1S/C14H13N3.ClH/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14;/h4-7,9-10,14H,1-3H2;1H
InChIKeyUKCVAQGKEOJTSR-UHFFFAOYSA-N
SMILESCl.N#Cc1ccc(cc1)C2CCCc3cncn23

鹽酸法倔唑 用途與合成方法

Fadrozole hydrochloride (CGS 16949A) 是一種有效,選擇性和非甾體類的 aromatase 抑制劑,其 IC50 值為 6.4 nM。

IC50: 6.4 nM (aromatase)

Fadrozole hydrochloride is a potent, selective and nonsteroidal inhibitor of aromatase with an IC 50 of 6.4 nM. In hamster ovarian slices, Fadrozole hydrochloride inhibits the production of estrogen with an IC 50 of 0.03 μM. The production of progesterone is inhibited with an IC 50 of 120 μM. Synthesis of other cytochrome P-450 dependent steroids can be suppressed to various degrees with higher doses of Fadrozole hydrochloride.

Fadrozole hydrochloride is able to inhibit the aromatase-mediated uterine hypertrophy in immature female rats with an ED 50 of 0.03 mg/kg when given orally. In the same model, aminoglutethimide elicits the same effect with an ED 50 of 30 mg/kg when given orally. Fadrozole hydrochloride prevents the development of both benign and malignant spontaneus mammary neoplasns in female Sprague-Dawley rats. It also slows the spontaneous development of ptuitary pars distalis adenomas in female rats, and reduces the incidence of spontaneous hepatocellular tumours in male and female rats. Administration of Fadrozole hydrochloride in male and female mice accompanies with a 70% reduction in parasite burden. This protective effect is associated in male mice with a recovery of the specific cellular immune response. Interleukin-6 (IL-6) serum levels, and its production by splenocytes, is augmented by 80%, together with a 10-fold increase in its expression in testes of infected male mice. Fadrozole hydrochloride treatment returns these levels to baseline values.

安全信息

危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼63-22
安全說(shuō)明36/37
危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1 / PGIII
WGK Germany2
RTECS號(hào)DI4952500
存儲(chǔ)類別6.1C - 可燃,急性毒性 類別3
毒性化合物或者引起慢性影響的化合物
危險(xiǎn)性類別急性毒性 類別3經(jīng)口
生殖毒性 類別2

MSDS信息

更新日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2025/12/22HY-14247鹽酸法倔唑
Fadrozole hydrochloride
102676-31-35mg660元
2025/12/22HY-14247鹽酸法倔唑
Fadrozole hydrochloride
102676-31-310mM * 1mLin DMSO726元
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