| Company Name: |
Haoyuan Chemexpress Co., Ltd.
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021-58950125 |
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info@chemexpress.com |
| Products Intro: |
Product Name:QL47
CAS:1469988-75-7
Purity:>98% Package:1100RMB/2mg
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QL47 manufacturers
- QL47
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- $69.00
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2026-04-22
- CAS:1469988-75-7
- Purity: 98.11%
- Supply Ability: 10g
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| Product Name: | QL47 | | Synonyms: | QL47;Benzo[h]-1,6-naphthyridin-2(1H)-one, 1-[2,3-dihydro-1-(1-oxo-2-propen-1-yl)-1H-indol-6-yl]-9-(1-methyl-1H-pyrazol-4-yl)-;BTK Inhibitor;QL47,QL-47;BMX/BTK Inhibitor II, QL47 | | CAS: | 1469988-75-7 | | MF: | C27H21N5O2 | | MW: | 447.49 | | EINECS: | | | Product Categories: | | | Mol File: | 1469988-75-7.mol |  |
| Boiling point | 706.2±60.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : < 1 mg/mL (insoluble or slightly soluble) | | form | Powder | | pka | 4+-.0.20(Predicted) | | color | Light yellow to yellow | | InChI | 1S/C27H21N5O2/c1-3-25(33)31-11-10-17-4-7-21(13-24(17)31)32-26(34)9-6-19-14-28-23-8-5-18(12-22(23)27(19)32)20-15-29-30(2)16-20/h3-9,12-16H,1,10-11H2,2H3 | | InChIKey | RTRNJQOBEOISFQ-UHFFFAOYSA-N | | SMILES | [n]1(ncc(c1)c2cc3c4[n]([c](ccc4cnc3cc2)=O)c5cc6c(cc5)CCN6C(=O)C=C)C |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| Uses | QL47, a broad-spectrum antiviral agent, inhibits dengue virus and other RNA viruses. QL47 selectively inhibits eukaryotic translation. QL47 is a potent covalent inhibitor of BTK with an IC50 of 7 nM[1][2][3]. | | Definition | ChEBI: 9-(1-methyl-4-pyrazolyl)-1-[1-(1-oxoprop-2-enyl)-2,3-dihydroindol-6-yl]-2-benzo[h][1,6]naphthyridinone is a naphthyridine derivative. | | Biological Activity | Cell permeable: yes', 'Primary Target
BMX & BTK', 'Reversible: no | | References | [1] Liang Y, et al. Structure-Activity Relationship Study of QL47: A Broad-Spectrum Antiviral Agent. ACS Med Chem Lett. 2017;8(3):344-349. Published 2017 Feb 3. DOI:10.1021/acsmedchemlett.7b00008
[2] de Wispelaere M, et al. A broad-spectrum antiviral molecule, QL47, selectively inhibits eukaryotic translation. J Biol Chem. 2020;295(6):1694-1703. DOI:10.1074/jbc.RA119.011132
[3] Wu H, et al. Discovery of a potent, covalent BTK inhibitor for B-cell lymphoma. ACS Chem Biol. 2014;9(5):1086-1091. DOI:10.1021/cb4008524 |
| | QL47 Preparation Products And Raw materials |
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