Product Details
| Product Name:
QL47 |
CAS No.:
1469988-75-7 |
| Purity:
98.11% |
Supply Ability:
10g |
| Release date:
2026/04/22 |
Product Introduction
Bioactivity
| Name | QL47 |
| Description | QL47 is a host-targeted small molecule antiviral agent with antiviral activity against dengue and other RNA viruses.QL47 acts as an inhibitor of viral translation and a covalent inhibitor of BTK, and can be used in the study of lymphomas. |
| In vitro | QL47 inhibits protein neosynthesis initiated by both canonical cap-driven and noncanonical initiation strategies, likely by targeting an early step in translation elongation[2]. With EC50 values of 475 nM and 318 nM, QL47 inhibits BTK autophosphorylation on Tyr223 and phosphorylation of the downstream effector PLCγ2 (Tyr759) in cells, respectively. In Ramos cells, QL47 induces G1 cell cycle arrest and significant BTK protein degradation. Additionally, QL47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 1 mg/mL (2.23 mM), Sonication is recommended.
|
| Keywords | VirusProtease | Virus Protease | QL-47 | QL47 | QL 47 | Dengue Fever virus | BTK |
| Inhibitors Related | Rifampicin | Phenytoin sodium | Levofloxacin hydrochloride | L-Lysine | L-Lysine hydrochloride | Penicillin G potassium | Ofloxacin | Sorbic acid | Vidarabine | (E)-3-(p-Tolyl)acrylaldehyde | Thymidine | Danthron |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Price |
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Suppliers |
Update time |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States