- Liquiritigenin
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- $10.00
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2026-05-28
- CAS:578-86-9
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 10 ton
- Liquiritigenin
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- $133.00
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2026-04-22
- CAS:578-86-9
- Purity: 99.25%
- Supply Ability: 10g
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| | LIQUIRITIGENIN Chemical Properties |
| Melting point | 206-208°C | | Boiling point | 529.5±50.0 °C(Predicted) | | density | 1.386±0.06 g/cm3(Predicted) | | Fp | 207℃ | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | DMSO : 125 mg/mL (487.80 mM; Need ultrasonic) | | form | powder | | pka | 7.71±0.40(Predicted) | | color | White | | BRN | 359378 | | Major Application | metabolomics
vitamins, nutraceuticals, and natural products | | Cosmetics Ingredients Functions | ANTIOXIDANT
SKIN CONDITIONING | | InChI | InChI=1S/C15H12O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-7,14,16-17H,8H2/t14-/m0/s1 | | InChIKey | FURUXTVZLHCCNA-AWEZNQCLSA-N | | SMILES | [C@H]1(C2=CC=C(O)C=C2)OC2=CC(O)=CC=C2C(=O)C1 |
| WGK Germany | 3 | | HS Code | 29329990 | | Storage Class | 11 - Combustible Solids |
| | LIQUIRITIGENIN Usage And Synthesis |
| Description | Liquiritigenin is an active estrogenic component in extracts of Glycyrrhizae radix. Glycyrrhizae radix (G. radix, licorice, liquorice) is frequently used for life-enhancing properties, for the treatment of injury or swelling, for detoxification in traditional Oriental medicine, as well as a food supplement in many of the countries in the world. Liquiritigenin is a selective estrogen receptor-β (ERβ) agonist. Liquiritigenin activates multiple ER regulatory elements and native target genes with ERβ but not ERα. The ERβ-selectivity of liquiritigenin is due to the selective recruitment of the coactivator steroid receptor coactivator-2 to target genes.
As the targeting ERβ is associated with anti-inflammatory effects, liquiritigenin exerts anti-inflammatory effects. Liquiritigenin is also reported to antihyperlipidemic, antiallergic and antihepatocellular carcinoma effects.
| | References | [1] J. E. Mersereau, N. Levy, R. E. Staub, S. Baggett, T. Zogric, S. Chow, W. A. Ricke, M. Tagliaferri, I. Cohen, L. F. Bjeldanes (2008) Liquiritigenin is a plant-derived highly selective estrogen receptor β agonist, Molecular and Cellular Endocrinology, 283, 49-57
[2] Di Wang, Jiahui Lu, Yan Liu, Qingfan Meng, Jing Xie, Zhenzuo Wang,Lesheng Teng (2014) Liquiritigenin Induces Tumor Cell Death through Mitogen-Activated Protein Kinase- (MPAKs-) Mediated Pathway in Hepatocellular Carcinoma Cells, BioMed Research International, 2014, Article ID 965316
| | Uses | Liquiritigenin has been used:
- to study its inhibitory effect on tumor metastasis in the treatment of colorectal cancer
- as a reference standard for ultra-performance liquid chromatography (UPLC) of Chaihu-Shugan-San (CSS) extract
- as a potential antiviral drug against hepatitis C virus (HCV) infection
| | Definition | ChEBI: A dihydroxyflavanone compound having the two hydroxy substituents at the 4'- and 7-positions. Isolated from the root of Glycyrrhizae uralensis, it is a selective agonist for oestrogen receptor beta. | | General Description | Liquiritigenin is a flavonoid and an estrogenic compound found in licorice (Glycyrrhizae radix) root extract and several other plants. | | Biochem/physiol Actions | Liquiritigenin displays anti-diabetic and choleretic properties. It exerts anti-inflammatory activity on Raw246.7 cells by inhibiting nuclear factor kappa light chain enhancer of activated B cells (NF-κB)-dependent-induction of inducible NOS (iNOS). Liquiritigenin inhibits liver fibrogenesis by blocking Hippo/Yes-associated protein (YAP) and transforming growth factor-β1 (TGF-β1)/small mothers against decapentaplegic (Smad) components. It is a selective estrogen receptor β agonist cells. Liquiritigenin induces apoptosis in SMM-721 cells by disruption of the mitochondrial membrane potential and increased production of reactive oxygen species. | | Purification Methods | It crystallises from aqueous 50% EtOH. [Beilstein 18 III/IV 1780, 18/4 V 82.] |
| | LIQUIRITIGENIN Preparation Products And Raw materials |
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