美托拉宗
| 中文名稱 | 美托拉宗 |
|---|---|
| 中文同義詞 | 7-氯-1,2,3,4-四氫-2-甲基-3-(2-甲基苯基)-4-氧代-6-喹唑磺酰胺;美托拉宗;美托拉宗(標(biāo)準(zhǔn)品);米托拉腙;甲醋唑胺;美托拉腙;美托拉宗雜質(zhì);美托拉索 EP標(biāo)準(zhǔn)品 |
| 英文名稱 | Metolazone |
| 英文同義詞 | s720-22;7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide, SR-720-22, Diulo, Metenix, Mykrox, Oldren,;6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo- (9CI);6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl- (8CI);Normelan;Xuret;6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro- 2-methyl-3-(2-methylphenyl)-4-oxo-;METAZOLINE |
| CAS號 | 17560-51-9 |
| 分子式 | C16H16ClN3O3S |
| 分子量 | 365.83 |
| EINECS號 | 241-539-3 |
| 相關(guān)類別 | 中間體;小分子抑制劑;科研試劑;利尿藥物;原料;醫(yī)藥原料;有機(jī)化工原料;ZAROXOLYN;Other APIs;Organics;Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Aromatics;Heterocycles;Sulfur & Selenium Compounds |
| Mol文件 | 17560-51-9.mol |
| 結(jié)構(gòu)式 | ![]() |
美托拉宗 性質(zhì)
| 熔點(diǎn) | 252-254°C |
|---|---|
| 沸點(diǎn) | 613.6±65.0 °C(Predicted) |
| 密度 | 1.2895 (rough estimate) |
| 折射率 | 1.6100 (estimate) |
| 儲存條件 | 2-8°C |
| 溶解度 | 二甲基亞砜:>5mg/mL |
| 酸度系數(shù)(pKa) | pKa 9.7 (Uncertain) |
| 形態(tài) | 固體 |
| 顏色 | 白色 |
| 水溶解性 | 60.3mg/L(25 ºC) |
| 穩(wěn)定性 | 自購買之日起 2 年內(nèi)保持穩(wěn)定。 DMSO 中的溶液可在 -20°C 下干燥保存長達(dá) 2 個(gè)月。 |
| 主要應(yīng)用 | 藥物(小分子) |
| InChI | 1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23) |
| InChIKey | AQCHWTWZEMGIFD-UHFFFAOYSA-N |
| SMILES | CC1Nc2cc(Cl)c(cc2C(=O)N1c3ccccc3C)S(N)(=O)=O |
| CAS 數(shù)據(jù)庫 | 17560-51-9(CAS DataBase Reference) |
| NIST化學(xué)物質(zhì)信息 | Metolazone(17560-51-9) |
Metolazone (SR-720-22) is a thiazide-like diuretic marketed under the brand names Zytanix from Zydus Cadila, Zaroxolyn, and Mykrox. It is primarily used to treat congestive heart failure and high blood pressure. Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases. This lowers blood pressure and prevents excess fluid accumulation in heart failure. Metolazone is sometimes used together with loop diuretics such as furosemide or bumetanide, but these highly effective combinations can lead to dehydration and electrolyte abnormalities. Metolazone and the other thiazide diuretics inhibit the function of the sodium-chloride symporter, preventing sodium and chloride, and therefore water too, from leaving the lumen to enter the tubule cell. As a result, water remains in the lumen and is excreted as urine, instead of being reabsorbed into the bloodstream. Since most of the sodium in the lumen has already been reabsorbed by the time the filtrate reaches the distal convoluted tubule, thiazide diuretics have limited effects on water balance and on electrolyte levels. Nevertheless, they can be associated with low sodium levels, volume depletion, and low blood pressure, among other adverse effects.
安全信息
| WGK Germany | 2 |
|---|---|
| RTECS號 | VA1700000 |
| 海關(guān)編碼 | 2935904000 |
| 存儲類別 | 11 - 可燃固體 |
| 毒害物質(zhì)數(shù)據(jù) | 17560-51-9(Hazardous Substances Data) |
| 毒性 | LD50 in mice (mg/kg): >5000 orally; >1500 i.p. (Shetty, 1967) |
| 提供商 | 語言 |
|---|---|
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英文
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| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/07/06 | S1610 | 美托拉宗 Metolazone | 17560-51-9 | 50mg | 812.06元 |
| 2026/07/06 | S1610 | 美托拉宗 Metolazone | 17560-51-9 | 1g | 5487.3元 |
