ChemicalBook CAS DataBase List 2-(Hydroxymethyl)pyridine

2-(Hydroxymethyl)pyridine synthesis

10synthesis methods

Product Name:2-(Hydroxymethyl)pyridine
CAS Number:586-98-1
Molecular formula:C6H7NO
Molecular Weight:109.13

The preparation of 2-(Hydroxymethyl)pyridine is as follows:NaOH (0.5 g, 12.5 mmol), Al2O3 (2.0 g, 19.6 mmol), aldehyde 1f-g (2 mmol) and H2O (400 μL) were grinded in a mortar. Next, the paste were placed in a glass 10 mL pressure vials and reaction was carried out in microwave reactor: standard mode (200 W), 100 °C, 2 min. After that, reaction mixture was extracted with DCM (2 × 20 mL). Organic layer was evaporated under reduce pressure yielding 2f-g. Solid residue was washed by water (2 × 15 mL). Aqueous phase was acidify with 1N HCl to pH 5.5 and centrifuged. After that aqueous layer was pour down and precipitate was lyophilisated. Products 3f-g were obtained as white solids.

2524-52-9 Synthesis

2524-52-9
289 suppliers
$6.00/5g

586-98-1
425 suppliers
$6.00/10g

Yield:586-98-1 99%

Reaction Conditions:

with C₃₀H₃₄Cl₂N₂P₂Ru;potassium methanolate;hydrogen in tetrahydrofuran at 100; under 38002.6 - 76005.1 Torr; for 24 h;Glovebox;Autoclave;

Steps:

27 Example 27: Hydrogenation of ester compounds catalyzed by ruthenium complex Ia

General procedure: In a glove box, add a ruthenium complex Ia (0.3 to 0.7 mg, 0.0002 to 0.001 mmol) to a 300 mL autoclave,Potassium methoxide (35-700 mg, 0.5-10 mmol), tetrahydrofuran (4-60 mL), and ester compounds (10-200 mmol).After sealing the autoclave, take it out of the glove box and fill it with 50 100atm of hydrogen.The reaction kettle was heated and stirred in an oil bath at 100 ° C for 10 to 336 hours.After the reaction kettle was cooled in an ice-water bath for 1.5 hours, the excess hydrogen was slowly released.The solvent was removed from the reaction solution under reduced pressure, and the residue was purified with a short silica gel column to obtain an alcohol compound. The results are shown in Table 5.

References:

CN110357923,2019,A Location in patent:Paragraph 0301-0303; 0306

2459-07-6 Synthesis

2459-07-6
239 suppliers
$5.00/1g

586-98-1
425 suppliers
$6.00/10g

References

31181-90-5 Synthesis

31181-90-5
369 suppliers
$5.00/250mg

586-98-1
425 suppliers
$6.00/10g

References

1007-49-4
30 suppliers
inquiry

586-98-1
425 suppliers
$6.00/10g

References

1121-60-4
523 suppliers
$10.60/10gm:

586-98-1
425 suppliers
$6.00/10g

References

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2-(Hydroxymethyl)pyridine synthesis

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