地榆皂苷Ⅱ
| 中文名稱 | 地榆皂苷Ⅱ |
|---|---|
| 中文同義詞 | 地榆皂苷 II;地榆皂苷II(標(biāo)準(zhǔn)品);地榆甙II;地榆皂苷LL;地榆皂苷II對照品,;地榆皂苷II、地榆苷Ⅱ;坡模酸-3-O-Α-L-吡喃阿拉伯糖苷;地榆皂苷Ⅱ |
| 英文名稱 | Ziyuglycoside II |
| 英文同義詞 | Ziyuglycoside II;(3beta)-3-(alpha-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid;Zigu-glucoside II;Gouguside 1;(3β)-3-(α-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid;Urs-12-en-28-oic acid, 3-(α-L-arabinopyranosyloxy)-19-hydroxy-, (3β)-;(3β)-3-(α-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oicaci;ZiyuglycosideⅡ |
| CAS號 | 35286-59-0 |
| 分子式 | C35H56O8 |
| 分子量 | 604.83 |
| EINECS號 | 233-305-4 |
| 相關(guān)類別 | 中藥對照品;標(biāo)準(zhǔn)品;植物提取物;對照品;植提標(biāo)準(zhǔn)品;分析試劑標(biāo)準(zhǔn)品;標(biāo)準(zhǔn)品-中藥標(biāo)準(zhǔn)品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;標(biāo)準(zhǔn)品-對照品;對照品-中藥對照品;標(biāo)準(zhǔn)品 -中藥標(biāo)準(zhǔn)品;三萜;標(biāo)準(zhǔn)品，對照品 |
| Mol文件 | 35286-59-0.mol |
| 結(jié)構(gòu)式 |  |
地榆皂苷Ⅱ 性質(zhì)
| 熔點 | 260-263℃ |
|---|---|
| 沸點 | 716.2±60.0 °C(Predicted) |
| 密度 | 1.25 |
| 儲存條件 | -20°C, protect from light |
| 溶解度 | 溶于DMSO和甲醇； |
| 酸度系數(shù)(pKa) | 4.47±0.70(Predicted) |
| 形態(tài) | 粉末 |
| 顏色 | 白色至米白色 |
| 水溶解性 | insoluble in water |
| InChIKey | MFIXLWYJTVEVGO-VHOGPVSJNA-N |
| SMILES | C[C@]12CC[C@H](O[C@]3([H])OC[C@H](O)[C@H](O)[C@H]3O)C(C)(C)[C@]1([H])CC[C@]4(C)[C@]2([H])CC=C5[C@@]4(C)CC[C@]6(C(O)=O)[C@@]5([H])[C@@](O)(C)[C@H](C)CC6 |
Ziyuglycoside II 是從 Sanguisorba officinalis L. 中提取的三萜皂苷化合物。Ziyuglycoside II 誘導(dǎo)活性氧 (ROS) 產(chǎn)生和凋亡 (apoptosis)。 具有抗炎和抗癌作用。
藥理藥效:具有一定的酪氨酸酶抑制作用，保肝利膽效果。
Ziyuglycoside II (10-60 μM; 24 h and 48 h) inhibits MDA-MB-435 cells growth in a dose-dependent manner. The IC
50
of Ziyuglycoside II at 24 h and 48 h is 5.92 μM and 4.74 μM, respectively.
Ziyuglycoside II (5-25 μM) induces G0/G1 and S phase arrest in MDA-MB-435 cells at 24 h.
Ziyuglycoside II (5-25 μM; 24 hours) significantly increases apoptotic rate of MDA-MB-435 cells.
Ziyuglycoside II (5-25 μM; 24 hours) increases expressions of both p53 and p21 in MDA-MB-435 cells, which effect is dose-dependent.
Cell Viability Assay
| Cell Line: | MDA-MB-435 cells |
| Concentration: | 10, 20, 30, 40, 50, 60 μM |
| Incubation Time: | 24 hours and 48 hours |
| Result: | The IC 50 at 24 h and 48 h was 5.92 μM and 4.74 μM, respectively. |
Cell Cycle Analysis
| Cell Line: | MDA-MB-435 cells |
| Concentration: | 5, 10, 25 μM |
| Incubation Time: | 24 hours |
| Result: | Induced G0/G1 and S phase arrest. |
Apoptosis Analysis
| Cell Line: | MDA-MB-435 cells |
| Concentration: | 5, 10, 25 μM |
| Incubation Time: | 24 hours |
| Result: | The apoptotic rate was significantly increased in comparison to that of the control. |
Western Blot Analysis
| Cell Line: | MDA-MB-435 cells |
| Concentration: | 5, 10, 25 μM |
| Incubation Time: | 24 hours |
| Result: | Treatment resulted in increased expressions of both p53 and p21. |
化學(xué)性質(zhì)
白色結(jié)晶體，可溶于甲醇、乙醇、DMSO等有機(jī)溶劑，來源于地榆。用途
地榆皂苷Ⅱ具有收縮血管，止血，抗真菌的作用。用途
用于含量測定/鑒定/藥理實驗等。藥理藥效:具有一定的酪氨酸酶抑制作用，保肝利膽效果。
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲類別 | 11 - 可燃固體 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-N0332 | 地榆皂苷Ⅱ Ziyuglycoside II | 35286-59-0 | 5mg | 550元 |
| 2026/06/05 | HY-N0332 | 地榆皂苷Ⅱ Ziyuglycoside II | 35286-59-0 | 10 mM * 1 mL in DMSO | 732元 |