SB 4
| 中文名稱 | SB 4 |
|---|---|
| 中文同義詞 | 2-((4-溴芐基)硫代)苯并[D]惡唑;化合物SB 4;SB 4,BMP4激動劑;化合物SB 4,10 MM DMSO 溶液;SB 4 試劑;SB 4 ,S0523;SB 4 試劑;SB 4,BMP4激動劑【CAS：100874-08-6】【規(guī)格：10mg】【純度：98%】 |
| 英文名稱 | SB 4 |
| 英文同義詞 | BMP signaling agonist sb4;SB 4;Benzoxazole, 2-[[(4-bromophenyl)methyl]thio]-;SB 4 (Eticovo);2-((4-Bromobenzyl)thio)benzo[d]oxazole;Inhibitor,SMAD,bmp,cell,inhibit,BMP signaling agonist sb4,BRE-luc,BMP signaling agonist sb 4,Transforming growth factor beta receptors,PREC,BMP signaling agonist sb-4,agonist,TGF-β Receptor;BMP signaling agonist sb4, 10 mM in DMSO;SB 4 ，S0523 |
| CAS號 | 100874-08-6 |
| 分子式 | C14H10BrNOS |
| 分子量 | 320.2 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 100874-08-6.mol |
| 結(jié)構(gòu)式 |  |
SB 4 性質(zhì)
| 熔點 | 70-72 °C |
|---|---|
| 沸點 | 444.2±47.0 °C(Predicted) |
| 密度 | 1.57±0.1 g/cm3(Predicted) |
| 儲存條件 | 2-8°C |
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 0.92±0.10(Predicted) |
| 顏色 | 白色至淺黃色 |
| InChI | 1S/C14H10BrNOS/c15-11-7-5-10(6-8-11)9-18-14-16-12-3-1-2-4-13(12)17-14/h1-8H,9H2 |
| InChIKey | JDVOIBFEFVKUPL-UHFFFAOYSA-N |
| SMILES | BrC1=CC=C(CSC2=NC3=C(C=CC=C3)O2)C=C1 |
SB 4 (Eticovo) 是一種 bone morphogenetic protein 4 (BMP4) signaling 的有效的選擇性激動劑，其EC50值為74 nM。SB 4 (Eticovo) 可增強經(jīng)典的BMP信號傳導(dǎo)并激活 SMAD-1/5/9 磷酸化。
| Target | Value |
|
BMP4
(Cell-free assay) | 74 nM(EC50) |
BMP signaling agonist sb4 (0.05 μM-1 μM; 24 hours) induces phosphorylated SMAD-1/5/9 in a dose-dependent manner in PRECs cells under serum-starved conitions. BMP signaling agonist sb4 (1 μM; 0-60 mins) enhances the efficacy of signaling at each concentration of rhBMP4 tested. This effect is most pronounced at low concentrations of rhBMP4, whereby sb4 increases BRE-luc expression 2-fold at 0.4 ng/ml of rhBMP4.
Western Blot Analysis
| Cell Line: | Primary mouse kidney epithelial cells (PRECs) |
| Concentration: | 0.05 μM-1 μM |
| Incubation Time: | 24 hours |
| Result: | Incresed p-SMAD-1/5/9 abundance in PRECs. |
Western Blot Analysis
| Cell Line: | BRE-Luc cells |
| Concentration: | 1 μM |
| Incubation Time: | 0min, 5 mins, 15 mins, 30 mins, 45 mins, 60 mins |
| Result: | Acted to stabilize p-SMAD-1/5/9 to enhance the transcriptional response. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲類別 | 11 - 可燃固體 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/07/06 | S0523 | SB 4 SB 4 (Eticovo) | 100874-08-6 | 5mg | 657.64元 |
| 2026/07/06 | S0523 | SB 4 SB 4 (Eticovo) | 100874-08-6 | 25mg | 1756.88元 |