| Company Name: |
Synthetic Research Pharma Laboratories Pvt Ltd
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| Tel: |
+91 9848023377 |
| Email: |
info@srplaboratories.com |
| Products Intro: |
Product Name:(2-amino-4-methylphenyl)methanol
CAS:81335-87-7
Purity:98% Package:1 kg,5 kg, 10 kg,25kg and 1 MT
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| | 4-METHYL-2-NITROBENZYLALCOHOL Basic information |
| | 4-METHYL-2-NITROBENZYLALCOHOL Chemical Properties |
| Boiling point | 295.4±25.0 °C(Predicted) | | density | 1.126±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 14.35±0.10(Predicted) | | Appearance | White to off-white Solid |
| | 4-METHYL-2-NITROBENZYLALCOHOL Usage And Synthesis |
| Synthesis | General procedure for the synthesis of (2-amino-4-methylphenyl)methanol from (4-methyl-2-nitrophenyl)methanol: General method: (4-methyl-2-nitrophenyl)methanol (12) was dissolved in ethanol (concentration 0.2 M) and palladium/carbon catalyst (10% w/w, 5 mol%) was added. The reaction mixture was stirred for 1 h at room temperature under hydrogen atmosphere. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and washed several times with ethyl acetate. The filtrate was concentrated under reduced pressure to obtain the crude product aniline, which was subsequently precipitated in a solvent mixture of petroleum ether and ethyl acetate (9:1, v/v). The precipitate was filtered and the solid was washed three times with a solvent mixture of the same ratio to give the final target product (2-amino-4-methylphenyl)methanol (11). | | References | [1] Synlett, 2017, vol. 28, # 14, p. 1724 - 1728
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 19, p. 5810 - 5831 |
| | 4-METHYL-2-NITROBENZYLALCOHOL Preparation Products And Raw materials |
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