4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID
| 中文名稱 | 4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID |
|---|---|
| 中文同義詞 | 化合物E4CPG |
| 英文名稱 | E4CPG |
| 英文同義詞 | E4CPG;(RS)-ALPHA-ETHYL-4-CARBOXYPHENYLGLYCINE;(RS)-α-Ethyl-4-carboxyphenylglycine;4-(1-amino-1-carboxypropyl)benzoic acid;Benzeneacetic acid, α-amino-4-carboxy-α-ethyl-;Metabotropic glutamate receptors,metabotropic,Inhibitor,mGluR,mGluRs,inhibit,(RS)-ECPG,E4CPG,E-4CPG |
| CAS號 | 170846-89-6 |
| 分子式 | C11H13NO4 |
| 分子量 | 223.23 |
| EINECS號 | |
| 相關(guān)類別 | Glutamate receptor |
| Mol文件 | Mol File |
| 結(jié)構(gòu)式 |  |
4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID 性質(zhì)
| 沸點 | 431.3±40.0 °C(Predicted) |
|---|---|
| 密度 | 1.337±0.06 g/cm3(Predicted) |
| 儲存條件 | Store at RT |
| 溶解度 | H2O：< 0.1 mg/mL（不溶）DMSO：< 1 mg/mL（不溶或微溶） |
| 形態(tài) | 粉末 |
| 酸度系數(shù)(pKa) | 1.76±0.10(Predicted) |
| 顏色 | 白色至米白色 |
E4CPG ((RS)-ECPG) 是一種 Group I/Group II 代謝型谷氨酸受體 (Group I/Group II metabotropic glutamate receptor) 的拮抗劑。E4CPG 可以抑制單突觸后機制中突觸后電流 (IPSC) 增強的成對脈沖比。
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mGluR
|
E4CPG acts at rat cortical mGluR with the K B value of 0.367 mM.
E4CPG (3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.), and 1-10 nmol/site (i.c.v.)) significantly inhibits the nociception induced by the Glutamate-injection (i.pl.; 30 μmol/paw), and the maximal inhibition values for the antinociceptive action of E4CPG in Glutamate-induced nociception are 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.) .
E4CPG (35 nM/3.5 μL, i.c.v.) completely blocks long-term depression (LTD) induced by the group I mGluR agonist Dihydroxyphenylglycine (DHPG, 100 nM/5 μL, i.c.v.) in male Sprague-Dawley rats.
| Animal Model: | Male Swiss mice (25-35 g) |
| Dosage: | 3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.) and 1-10 nmol/ site (i.c.v.) |
| Administration: | Single injection |
| Result: | The maximal inhibition values for the antinociceptive action of E4CPG in glutamate-induced nociception were 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.). |
| Animal Model: | Male Sprague-Dawley rats |
| Dosage: | 35 nM/3.5 μL |
| Administration: | Single injection, i.c.v. |
| Result: | Completely blocked LTD induced by the group I mGluR agonist dihydroxyphenylglycine (DHPG). |
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-100372 | 4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID E4CPG | 170846-89-6 | 5mg | 600元 |
| 2025/12/22 | HY-100372 | 4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID E4CPG | 170846-89-6 | 10mg | 800元 |