(+/-)MCPG
| 中文名稱 | (+/-)MCPG |
|---|---|
| 中文同義詞 | (±)-Α-甲基-(4-羧苯基)甘氨酸;ALPHA-氨基-4-羧基-ALPHA-甲基-苯乙酸;(±)-Α-METHYL-(4-CARBOXYPHENYL)GLYCINE;(R,S)-Α-甲基-4-羧苯基甘氨酸;化合物(RS)-MCPG;4-(1-氨基-1-羧乙基)苯甲酸;(±)-Α-甲基-(4-羧基苯基)甘氨酸;(R,S)-MCPG,GROUP I /II METABOTROPIC GLUTAMATE拮抗劑 |
| 英文名稱 | (RS)-MCPG |
| 英文同義詞 | (+/-)MCPG;(+/-)-ALPHA-METHYL-(4-CARBOXYPHENYL)GLYCINE;(RS)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE;(RS)-A-METHYL-4-CARBOXYPHENYLGLYCINE;(RS)-MCPG;(+/-)-A-METHYL-(4-CARBOXYPHENYL)GLYCINE;(+-)-A-METHYL-4-CARBOXYPHENYLGLYCINE MET ABOTROPIC GLUTAMAT;[+/-]-MCPG |
| CAS號(hào) | 146669-29-6 |
| 分子式 | C10H11NO4 |
| 分子量 | 209.2 |
| EINECS號(hào) | |
| 相關(guān)類別 | Glutamate;Glutamate receptor |
| Mol文件 | 146669-29-6.mol |
| 結(jié)構(gòu)式 |  |
(+/-)MCPG 性質(zhì)
| 沸點(diǎn) | 425.3±40.0 °C(Predicted) |
|---|---|
| 密度 | 1.390±0.06 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Keep in dark place,Inert atmosphere,Room temperature |
| 溶解度 | DMSO：6 mg/mL（28.68 mM；需要超聲波和加熱） |
| 形態(tài) | 粉末 |
| 酸度系數(shù)(pKa) | 1.76±0.10(Predicted) |
| 顏色 | 白色 |
| InChI | 1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15) |
| InChIKey | DNCAZYRLRMTVSF-UHFFFAOYSA-N |
| SMILES | CC(N)(C(O)=O)c1ccc(cc1)C(O)=O |
| CAS 數(shù)據(jù)庫(kù) | 146669-29-6(CAS DataBase Reference) |
(RS)-MCPG (alpha-MCPG) 是一種競(jìng)爭(zhēng)性和選擇性 I/II 組代謝型谷氨酸受體 (mGluR) 拮抗劑。(RS)-MCPG 阻斷 TBS 誘導(dǎo)的幼年和新生大鼠海馬神經(jīng)元的轉(zhuǎn)變。
group I/group II mGluR
MCPG can block group I (mGluR1 and mGluR5) and group II receptors (mGluR2 and mGluR3).
(RS)-MCPG (alpha-MCPG; 500 μM) blocks the TBS-induced shifts in EGABA in either juvenile or neonatal neurons.
Pretreatment with the low dose of (RS)-MCPG (25 nM; i.c.; daily; 5 days) significantly attenuates amphetamine-induced locomotor activity in 10-day-old male and female rats of Sprague-Dawley descent.
安全信息
| WGK Germany | 3 |
|---|---|
| 存儲(chǔ)類別 | 11 - 可燃固體 |
| 提供商 | 語言 |
|---|---|
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英文
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| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-100371 | (RS)-MCPG | 146669-29-6 | 1 mg | 304元 |
| 2025/12/22 | HY-100371 | (+/-)MCPG (RS)-MCPG | 146669-29-6 | 5mg | 690元 |