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BOC Sciences
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Product Name:L-902,688
CAS:634193-54-7
Purity:>=98% Remarks:Reach out to us for more information about custom solutions.
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| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 |
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sales@glpbio.cn |
| Products Intro: |
Product Name:L-902,688
CAS:634193-54-7
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:L-902,688
CAS:634193-54-7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
L-902,688 manufacturers
- L-902688
-
- $768.00
-
2026-07-17
- CAS:634193-54-7
- Purity:
- Supply Ability: 10g
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| | L-902,688 Basic information |
| Product Name: | L-902,688 | | Synonyms: | L-902,688;L-902,688 Exclusive;(5R)-5-[(E,3R)-4,4-difluoro-3-hydroxy-4-phenylbut-1-enyl]-1-[6-(2H-tetrazol-5-yl)hexyl]pyrrolidin-2-one;2-Pyrrolidinone, 5-[(1E,3R)-4,4-difluoro-3-hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5-yl)hexyl]-, (5R)-;L902688,L 902688;1-(6-(2H-Tetrazol-5-yl)hexyl)-5-((R)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl)pyrrolidin-2-one , L-902688;L-902688, 5mg/ml in methanol;L-902,688(solution in ethanol) | | CAS: | 634193-54-7 | | MF: | C21H27F2N5O2 | | MW: | 419.468 | | EINECS: | | | Product Categories: | | | Mol File: | 634193-54-7.mol |  |
| | L-902,688 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF:30.0(Max Conc. mg/mL);71.52(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);71.52(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);71.52(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.19(Max Conc. mM) | | form | Liquid | | color | Colorless to light yellow |
| | L-902,688 Usage And Synthesis |
| Description | Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. L-902,688 is a highly potent agonist of the human PGE2 receptor, EP4. It demonstrates a Ki value of 0.38 nM and an EC50 value of 0.6 nM and is >4,000-fold selective for EP4 over other EP and prostanoid receptors. L-902,688 induces thermal hyperalgesia when injected into guinea pig forepaw and increases vasodilation of human pulmonary vein. | | Uses | L-902688 is a potent, selective and orally active EP4 receptor agonist with a Ki of 0.38 nM and an EC50 of 0.6 nM. L-902688 shows >4,000-fold selective for EP4 over other EP and prostanoid receptors[1][2]. | | in vivo | L-902688 (0.25-1 μg/kg/day; intraperitoneal injection; daily; for 3 weeks; adult male Sprague-Dawley rats) treatment reduces right ventricle fibrosis in the monocrotaline (MCT)-induced PAH rat model[1]. | Animal Model: | Adult male Sprague-Dawley rats injected with crotaline to induce pulmonary arterial hypertension (PAH) and right ventricular (RV) hypertrophy[1] | | Dosage: | 0.25 μg/kg/day, 0.4 μg/kg/day or 1 μg/kg/day | | Administration: | Intraperitoneal injection; daily; for 3 weeks | | Result: | Reduced right ventricle fibrosis in the monocrotaline (MCT)-induced PAH rat model. |
| | IC 50 | EP4: 0.38 nM (Ki); EP4: 0.6 nM (EC50) | | References | [1] Lai YJ, et al. EP4 Agonist L-902,688 Suppresses EndMT and Attenuates Right Ventricular Cardiac Fibrosis in Experimental Pulmonary Arterial Hypertension. Int J Mol Sci. 2018 Mar 3;19(3). pii: E727. DOI:10.3390/ijms19030727
[2] [2]Young, R.N., Billot, X., Han, Y., et al. Discovery and synthesis of a potent, selective and orally bioavailable EP4 receptor agonist. Heterocycles. 2004, 64, 437-445. |
| | L-902,688 Preparation Products And Raw materials |
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