L-902688 NEW
| Price | $768 | $3420 | $5920 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-17 |
Product Details
| Product Name: L-902688 | CAS No.: 634193-54-7 |
| Supply Ability: 10g | Release date: 2026/07/17 |
Product Introduction
Bioactivity
| Name | L-902688 |
| Description | L-902688 is a potent, highly selective and orally active EP4 receptor agonist with a Ki value of 0.38 nM and an EC50 value of 0.6 nM. Its selectivity for the EP4 receptor is more than 4000-fold higher than that for other EP receptors and prostanoid receptors. |
| In vitro | Methods: Human umbilical vein endothelial cells (HUVECs) were treated with 1 μM L-902688 for 24 hours to detect its effect on the expression of Twist and α-smooth muscle actin (α-SMA) induced by TGF-β. Results: L-902688 (1 μM, 24 h) could significantly inhibit the TGF-β-induced upregulation of Twist and α-SMA expression in HUVECs [1]. |
| In vivo | Methods: Adult male SD rats were intraperitoneally injected with L-902688 at a dose of 0.25–1 μg/kg per day once daily for 3 weeks. The degree of right ventricular fibrosis was evaluated in a monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) model. Results: L-902688 (0.25–1 μg/kg/day, intraperitoneal injection, once daily for 3 consecutive weeks) could attenuate right ventricular fibrosis in MCT-induced PAH rats [1]. |
| Storage | Store at low temperature Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | ProstaglandinReceptor | Prostaglandin Receptor | L-902688 | EP4 |
| Inhibitors Related | Angoroside C | Pranoprofen | Tranilast | Tetrahexyldecyl ascorbate | Rutin | Ozagrel | Ethamsylate | Rebamipide | Evodiamine | Lornoxicam | Nepafenac | p-Hydroxycinnamic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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