Diprotin A TFA (Synonyms: Ile-Pro-Pro (TFA)) manufacturers
- Diprotin A TFA
-
- $49.00
-
2026-05-11
- CAS:209248-71-5
- Purity:
- Supply Ability: 10g
|
| | Diprotin A TFA (Synonyms: Ile-Pro-Pro (TFA)) Basic information |
| | Diprotin A TFA (Synonyms: Ile-Pro-Pro (TFA)) Chemical Properties |
| storage temp. | Store at -20°C | | form | Solid | | color | White to off-white | | Water Solubility | Water : ≥ 77.5 mg/mL (170.15 mM) |
| | Diprotin A TFA (Synonyms: Ile-Pro-Pro (TFA)) Usage And Synthesis |
| Uses | Diprotin A TFA (Ile-Pro-Ile TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV)[1]. | | in vivo | In the model of retinopathy of prematurity, Diprotin A increases not only retinal vascularity but also leakage. Additionally, in the murine diabetic retinopathy model, Diprotin A increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway[1]. | | IC 50 | DPP-4 | | References | [1] Lee CS, et al. Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation. Sci Rep. 2016 Jul 6;6:29393. DOI:10.1038/srep29393 |
| | Diprotin A TFA (Synonyms: Ile-Pro-Pro (TFA)) Preparation Products And Raw materials |
|