| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
18210857532 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:5-iodo-2,6-dimethyl-4-pyrimidinol(SALTDATA: FREE)
CAS:83410-37-1
Purity:95% Package:250MG
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| Company Name: |
SuZhou ShiYa Biopharmaceuticals, Inc.
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| Tel: |
86(512)5235 8471 17715136450 |
| Email: |
sales@shiyabiopharm.com |
| Products Intro: |
Product Name:5-Iodo-2,6-diMethyl-1H-pyriMidin-4-one
CAS:83410-37-1
Purity:>96% Package:1g;5g;25g Remarks:S1-2031A
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2,6-DIMETHYL-5-IODO-4(3H)-PYRIMIDONE manufacturers
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| | 2,6-DIMETHYL-5-IODO-4(3H)-PYRIMIDONE Basic information |
| Product Name: | 2,6-DIMETHYL-5-IODO-4(3H)-PYRIMIDONE | | Synonyms: | 2,6-DIMETHYL-5-IODO-4(3H)-PYRIMIDONE;5-iodo-2,6-dimethyl-4-pyrimidinol(SALTDATA: FREE);5-Iodo-2,6-diMethyl-1H-pyriMidin-4-one;5-iodo-2,6-dimethyl-4(3H)-Pyrimidinone;4(3H)-Pyrimidinone, 5-iodo-2,6-dimethyl-;5-Iodo-2,6-dimethylpyrimidin-4(3h)-one | | CAS: | 83410-37-1 | | MF: | C6H7IN2O | | MW: | 250.04 | | EINECS: | | | Product Categories: | | | Mol File: | 83410-37-1.mol |  |
| | 2,6-DIMETHYL-5-IODO-4(3H)-PYRIMIDONE Chemical Properties |
| Melting point | 196-199 °C | | Boiling point | 254.9±43.0 °C(Predicted) | | density | 2.03±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | pka | 8.33±0.50(Predicted) |
| | 2,6-DIMETHYL-5-IODO-4(3H)-PYRIMIDONE Usage And Synthesis |
| Synthesis | Step A: 2,6-Dimethylpyrimidin-4-ol (5.0 g, 40 mmol) was dissolved in aqueous sodium hydroxide solution (50 mL, 1 M, 50 mmol). Iodine (10.2 g, 40 mmol) was subsequently added to this solution. The reaction mixture was slowly warmed to 80 °C and stirred continuously for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted with acetic acid to about 6. At this point, a precipitate appeared in the reaction mixture and the precipitate was collected by filtration. The resulting solid was washed with deionized water and dried to give the target product 5-iodo-2,6-dimethylpyrimidin-4-ol (6.51 g, 65% yield). Mass spectrometry analysis showed m/z 251.2 [M + H]+. | | References | [1] Patent: US9617268, 2017, B2. Location in patent: Page/Page column 398
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 22, p. 4251 - 4260
[3] Tetrahedron, 2007, vol. 63, # 9, p. 1931 - 1936
[4] Patent: US5466692, 1995, A
[5] Patent: US2012/95031, 2012, A1. Location in patent: Page/Page column 160 |
| | 2,6-DIMETHYL-5-IODO-4(3H)-PYRIMIDONE Preparation Products And Raw materials |
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