2-Bromo-1-(bromomethyl)-4-fluorobenzene

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Products Intro: Product Name:2-Bromo-4-fluorobenzylbromide
CAS:61150-57-0
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CAS:61150-57-0
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CAS:61150-57-0
Purity:99% Package:1kg

2-Bromo-1-(bromomethyl)-4-fluorobenzene manufacturers
2-Bromo-1-(bromomethyl)-4-fluorobenzene Basic information
Product Name:2-Bromo-1-(bromomethyl)-4-fluorobenzene
Synonyms:2-BROMO-4-FLUOROBENZYL BROMIDE;2-BROMO-1-(BROMOMETHYL)-4-FLUOROBENZENE;2-Bromo-4-Fluorobenzyl;2-BroMo-1-(broMoMeth;2-Bromo-1-(bromomethyl)-4-fluorobenzene, alpha,2-Dibromo-4-fluorotoluene;Benzene, 2-bromo-1-(bromomethyl)-4-fluoro-;2-Bromine-4-Fluoride Bromine Benzyl;2-Bromo-4-fluorobenzylbromide,96%
CAS:61150-57-0
MF:C7H5Br2F
MW:267.92
EINECS:
Product Categories:Fluorine series;Aromatic Hydrocarbons (substituted) & Derivatives;alkyl bromide| alkyl Fluorine
Mol File:61150-57-0.mol
2-Bromo-1-(bromomethyl)-4-fluorobenzene Structure
2-Bromo-1-(bromomethyl)-4-fluorobenzene Chemical Properties
Boiling point 254.0±25.0 °C(Predicted)
density 1.923±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form Solid
AppearanceOff-white to light yellow Crystal
CAS DataBase Reference61150-57-0(CAS DataBase Reference)
Safety Information
RIDADR 3261
HazardClass 8
PackingGroup Ⅲ
HS Code 2903998090
MSDS Information
2-Bromo-1-(bromomethyl)-4-fluorobenzene Usage And Synthesis
Chemical Propertieswhite crystal powde
Synthesis
2-Bromo-4-fluorotoluene

1422-53-3

2-Bromo-1-(bromomethyl)-4-fluorobenzene

61150-57-0

General procedure for the synthesis of 2-bromo-4-fluorobenzyl bromide from 2-bromo-4-fluorotoluene: In a round-bottomed flask equipped with a reflux condenser, 2-bromo-4-fluorotoluene (15 g, 79.3 mmol), N-bromosuccinimide (18.08 g, 101.6 mmol) and 2,2'-azobisisobutyronitrile (3.9 g, 23.8 mmol) were dissolved in carbon tetrachloride (150 mL). The reaction mixture was heated to reflux for 21 hours. After completion of the reaction, the mixture was cooled and the solvent was removed by distillation under reduced pressure. The crude product was suspended in dichloromethane and the organic layer was washed with water. Subsequently, the organic layer was washed with saturated aqueous sodium chloride solution and dried with anhydrous sodium sulfate. After filtration, the solvent was removed by distillation under reduced pressure to obtain the crude product. Purification of the crude product by column chromatography (eluent: 1% hexane solution of ethyl acetate tapered to 10% hexane solution of ethyl acetate) afforded 2-bromo-4-fluorobenzyl bromide as an oily white solid (18.5 g, 87% yield).GC-MS analysis showed m/z 268 [M]+.

References[1] Synlett, 2011, # 17, p. 2525 - 2528
[2] Patent: WO2008/144223, 2008, A2. Location in patent: Page/Page column 28
[3] Patent: WO2007/70041, 2007, A1. Location in patent: Page/Page column 126
[4] Journal of Medicinal Chemistry, 2003, vol. 46, # 3, p. 409 - 416
[5] Collection of Czechoslovak Chemical Communications, 1999, vol. 64, # 4, p. 649 - 672
2-Bromo-1-(bromomethyl)-4-fluorobenzene Preparation Products And Raw materials
Raw materials2-Bromo-4-fluorotoluene-->Carbon tetrachloride-->AIBN-->N-Bromosuccinimide
Preparation Products4-BROMO-6-FLUOROINDAN-1-ONE-->2-Bromo-4-fluorophenylacetic acid
Tag:2-Bromo-1-(bromomethyl)-4-fluorobenzene(61150-57-0) Related Product Information
alpha-Chloro-o-fluorotoluene BRETYLIUM TOSYLATE Ethyl bromodifluoroacetate [2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 2,2-dimethyl-3-pro p-1-enyl-cyclopropane-1-carboxylate 4-Fluorobenzyl chloride 2-Bromo-4-fluorotoluene 3-Fluorobenzyl bromide BROMOTRIFLUOROMETHANE Bromine 4-Fluorobenzyl bromide Fluorobenzene 1-Bromo-2-(bromomethyl)-4-fluorobenzene 1-Bromo-4-bromomethyl-3-fluorobenzene 1-Bromo-3-bromomethyl-2-fluorobenzene TETRABROMO-4-FLUORO-O-XYLENE 2-Bromo-1-(bromomethyl)-4-fluorobenzene 3-bromo-4-fluorobenzyl bromide 1-bromo-4-(bromomethyl)-2-fluorobenzene