R162
| 中文名稱 | R162 |
|---|---|
| 中文同義詞 | 化合物R162;2-烯丙基-1-羥基蒽-9,10-二酮;R162,谷氨酸脫氫酶(GDH1)抑制劑;化合物R162,10 MM DMSO 溶液;谷氨酸脫氫酶(GDH1)抑制劑 |
| 英文名稱 | R162 |
| 英文同義詞 | R162;R-162;R 162;R162, >98%;2-Allyl-1-hydroxy-9,10-anthraquinone;9,10-Anthracenedione, 1-hydroxy-2-(2-propen-1-yl)-;R162,inhibit,R-162,Inhibitor,R 162;9,10-Anthracenedione, 1-hydroxy-2-(2-propenyl)-;R162, 10 mM in DMSO;2-ALLYL-1-HYDROXY-ANTHRAQUINONE |
| CAS號 | 64302-87-0 |
| 分子式 | C17H12O3 |
| 分子量 | 264.28 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 64302-87-0.mol |
| 結(jié)構(gòu)式 |  |
R162 性質(zhì)
| 熔點 | 120-120.5 °C(Solv: acetone (67-64-1)) |
|---|---|
| 沸點 | 459.0±34.0 °C(Predicted) |
| 密度 | 1.308±0.06 g/cm3(Predicted) |
| 儲存條件 | -20°C |
| 溶解度 | 可溶于DMSO（高達(dá)10mg/ml）或乙醇（高達(dá)5mg/ml） |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 7.43±0.20(Predicted) |
| 顏色 | 橙色 |
| 穩(wěn)定性 | 自購買之日起，穩(wěn)定期為 1 年。 其DMSO 或乙醇溶液可在 -20°C 下保存長達(dá) 3 個月。 |
Inhibition of GDH1 activity by R162 treatment results in decreased intracellular fumarate levels, attenuated GPx activity, increased ROS levels, and reduced cell proliferation in H1299 and MDA-MB231 cells, which can be significantly rescued by methyl-α-KG treatment as well as by antioxidant NAC. R162 inhibits cell proliferation and tumor growth potential of human cancer cells.
R162 (30 mg/kg/day, i.p.) does not result in a significant histopathological change between the vehicle-treated and R162-treated groups, nor alters complete blood counts, or hematopoietic properties in xenograft tumor mouse models. R162 (20 mg/kg/day) results in significantly decreased tumor growth and masses in mice compared with control mice and effectively inhibits GDH1 activity in resected tumors from xenograft nude mice.
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-103096 | R162 R162 | 64302-87-0 | 1 mg | 400元 |
| 2026/06/05 | HY-103096 | R162 R162 | 64302-87-0 | 5 mg | 880元 |