4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide

4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:Heptamidine；SBi4211
CAS:94345-47-8
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:Heptamidine
CAS:94345-47-8
Package:100mg;2500USD|50mg;1980USD|25mg;1520USD
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:Heptamidine
CAS:94345-47-8
Package:100mg;2500USD|50mg;1980USD|25mg;1520USD
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
Tel: 15076683720
Email: klq@cw-bio.com
Products Intro: Product Name:Heptamidine
CAS:94345-47-8
Purity:≥98% Package:100mg 1g,5g,根據(jù)客戶需要分裝 Remarks:Not For Human Use, Lab Use Only.
Company Name: Shanghai Hongye Biotechnology Co. Ltd  
Tel: 400-9205774
Email: sales@glpbio.cn
Products Intro: Product Name:Heptamidine
CAS:94345-47-8
Purity:>98% Package:1mg;10mg;50mg;100mg;

4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide manufacturers

  • Heptamidine
  • Heptamidine pictures
  • $2500.00
  • 2026-04-20
  • CAS:94345-47-8
  • Purity:
  • Supply Ability: 10g
  • Heptamidine
  • Heptamidine pictures
  • $2500.00
  • 2025-07-21
  • CAS:94345-47-8
  • Purity:
  • Supply Ability: 10g
4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide Basic information
Product Name:4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide
Synonyms:4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide;Heptamidine;SBi4211;Benzenecarboximidamide, 4,4'-[1,7-heptanediylbis(oxy)]bis-
CAS:94345-47-8
MF:C21H28N4O2
MW:368.47
EINECS:
Product Categories:
Mol File:94345-47-8.mol
4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide Structure
4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide Chemical Properties
Melting point 175-177 °C (decomp)
Boiling point 558.0±60.0 °C(Predicted)
density 1.17±0.1 g/cm3(Predicted)
pka12.81±0.50(Predicted)
Safety Information
MSDS Information
4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide Usage And Synthesis
UsesHeptamidine (SBi4211) is a potent Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd=6.9 μM), selectively kills melanoma cells with S100B over those without S100B[1]. Heptamidine is a useful tool for the investigation of Myotonic dystrophy (DM)[2].
in vivo

Heptamidine (intraperitoneal injection; 20 or 30 mg/kg; 7 days) causes a dose-dependent reduction of exon 7a inclusion inHSALRmice, returning to wild type levels (6±1%) when at 20 mg/kg dose, the myotonia is reduced from grade 3 to grade 1 (occasional myotonic discharge) or grade 0 at both 20 or 30 mg/kg[2].

Animal Model:HomozygousHSALRtransgenic mice in line 20b (FVB inbred background)with a Myotonic dystrophy (DM) mouse model[2]
Dosage:20 or 30 mg/kg
Administration:Intraperitoneal injection; 7 days; once daily
Result:Reversed splicing defects and rescues myotonia in a DM mouse model.
References[1] McKnight LE, et al. Structure-Based Discovery of a Novel Pentamidine-Related Inhibitor of the Calcium-Binding Protein S100B. ACS Med Chem Lett.2012Dec 13;3(12):975-979. Epub2012Sep 25. DOI:10.1021/ml300166s
[2] Coonrod LA, et al. Reducing levels of toxic RNA with small molecules.ACS Chem Biol.2013 Nov 15;8(11):2528-37. DOI:10.1021/cb400431f
4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide Preparation Products And Raw materials
Raw materialsBenzonitrile, 4,4'-[1,7-heptanediylbis(oxy)]bis-
Tag:4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide(94345-47-8) Related Product Information