Heptamidine NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-20 |
Product Details
| Product Name: Heptamidine | CAS No.: 94345-47-8 |
| Supply Ability: 10g | Release date: 2026/04/20 |
Product Introduction
Bioactivity
| Name | Heptamidine |
| Description | Heptamidine is an effective Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd: 6.9 μM). It selectively kills melanoma cells with S100B over those without S100B. It is a useful tool for the investigation of Myotonic dystrophy. |
| In vitro | Heptamidine is a Pentamidine-S100B complex with two pentamidine molecules binding per monomer of S100B, acting as an inhibitor for S100B[1]. It rescues mis-splicing of minigene reporters in a HeLa cell DM1 model with an EC50 value of 15 μM. Compared to Propamidine and Pentamidine, Heptamidine (20 μM) does not significantly reduce CUG levels. It exhibits cytotoxicity at concentrations above 17.5 μM in HeLa cells expressing 960 CUG repeats[2]. |
| In vivo | Heptamidine (intraperitoneal injection; 20 or 30 mg/kg; 7 days) induces a dose-dependent reduction of exon 7a inclusion in HSALR mice, returning to wild-type levels (6±1%) at a 20 mg/kg dose. Myotonia is reduced from grade 3 to grade 1 (occasional myotonic discharge) or grade 0 at both 20 and 30 mg/kg [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Heptamidine | calcium-binding protein S100B |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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TargetMol Chemicals Inc.
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TargetMol Chemicals Inc.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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