2-Hydroxysaclofen NEW
| Price | $326 | $778 |
| Package | 10mg | 50mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: 2-Hydroxysaclofen | CAS No.: 117354-64-0 |
| Purity: 98.56% | Supply Ability: 10g |
| Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | 2-Hydroxysaclofen |
| Description | 2-Hydroxysaclofen is a potent γ-amino-butyric-acid-B receptor antagonist that effectively abolishes nicotine-induced hypolocomotor effects, enhances antinociceptive responses, and stimulates luteinizing hormone secretion in female rats, making it a valuable pharmacological probe for investigating GABAB receptor–mediated neuroendocrine regulation and behavioral pharmacology. |
| In vivo | In male Swiss Webster mice, intraperitoneal (IP) administration of 2-Hydroxysaclofen (0.25-1 mg/kg) modulates the acute effects of nicotine. At a dose of 1 mg/kg, it abolishes nicotine-induced hypolocomotion while enhancing its antinociceptive effects. In male Wistar rats, IP administration (0.3-3 mg/kg) antagonizes the ability of Baclofen to alter the discriminative stimulus effects of d-amphetamine. Furthermore, in estrogen-primed ovariectomized female rats, intracerebroventricular (ICV) injection (50-100 ug/mL) leads to an elevation in serum Luteinizing Hormone (LH) concentrations, with peak levels observed 10 minutes post-injection [1][2][3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 1M NaOH : 25 mg/mL (94.09 mM), Sonication is recommended. H2O : 40 mg/mL (150.54 mM), when pH is adjusted to 11 with 1 M NaOH. Sonication is recommmended. 1eq. NaOH : 100 mM, Sonication is recommended. |
| Keywords | 2-Hydroxysaclofen | 2Hydroxysaclofen | 2 Hydroxysaclofen |
| Inhibitors Related | Valproic acid sodium salt | p-Hydroxybenzaldehyde | Urethane | Baicalin | Imidazoleacetic acid hydrochloride | Penicillin G sodium salt | Valproic Acid | Methyl eugenol | (-)-α-Pinene | Nipecotic acid | Dihydromyricetin | Methionine |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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