MI-2-2 NEW
| Price | $58 | Get Latest Price |
| Package | 1mg | 5mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-30 |
Product Details
| Product Name: MI-2-2 | CAS No.: 1454920-20-7 |
| Purity: 99.65% | Supply Ability: 10g |
| Release date: 2026/05/30 |
Product Introduction
Bioactivity
| Name | MI-2-2 |
| Description | MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM. |
| In vitro | MI-2-2 inhibits the bivalent fragment of MLL, consisting of MBM1 and MBM2, with an IC50 of 520 nM. It effectively suppresses cell proliferation, differentiation, and Hoxa9 expression. Additionally, MI-2-2 shows significant activity at low micromolar concentrations in BMCs transformed with MLL-AF9 and in MV4[1]. |
| Storage | Keep away from direct sunlight,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : Soluble |
| Keywords | MI-2-2 | MI-22 | MI 22 | menin-MLL interaction | Menin-MLL | leukemia | Inhibitor | inhibit | Hoxa9 expression | HistoneMethyltransferase | Histone Methyltransferase | Epigenetic Reader Domain | differentiation | cell proliferation |
| Inhibitors Related | MAK-683 hydrochloride | ABBV-744 | 3-methyl-1,2,3,4-tetrahydroquinazolin-2-one | Tazemetostat | Piribedil | 5-Ph-IAA | Curcumin | EPZ015666 | iso-Azalansta | Naphthol AS-E | MRTX-1719 | JQ-1 (carboxylic acid) |
| Related Compound Libraries | Histone Modification Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Epigenetics Compound Library | Post-Translational Modification Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Cancer Compound Library | High-Efficiency Gene Editing Small Molecule Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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