Product Details
| Product Name:
MI-192 |
CAS No.:
1415340-63-4 |
| Supply Ability:
10g |
Release date:
2025/12/22 |
Product Introduction
Bioactivity
| Name | MI-192 |
| Description | MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC50 values of 30 nM and 16 nM, respectively. It exhibits greater selectivity for HDAC2/3 over other HDAC isomers and induces apoptosis in myeloid leukemic cells, indicating potential therapeutic use in leukemia and as an anti-stroke agent [1] [2]. |
| In vitro | MI-192, at concentrations ranging from 0.15 to 1 μM over a period of 72 hours, both induces differentiation and exerts cytotoxic effects through apoptosis promotion in the acute myeloid leukemia cell lines U937, HL60, and Kasumi-1 [1]. Specifically, apoptosis analysis revealed that MI-192, at concentrations of 150 nM, 300 nM, 500 nM, and 1 μM, significantly induced apoptosis in HL60 and Kasumi-1 cells after a 72-hour incubation [1]. |
| In vivo | MI-192 (40 mg/kg; i.p.; once a day for 3 days) exhibits neuroprotective effects in adult male outbred CD-1 mice (20-25 g) with photothrombotic stroke (PTS). It significantly reduces PTS-induced brain infarction volume, improves forelimb functional symmetry, decreases PTS-induced apoptosis and α-tubulin acetylation, and increases GAP-43 expression in the affected cerebral cortex. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | MI192 | MI-192 | MI 192 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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