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Postion:Product Catalog >Analytical Chemistry>Standard>Pharmaceutical Impurity Reference Standards>3-Hydroxy agomelatine
3-Hydroxy agomelatine
  • 3-Hydroxy agomelatine

3-Hydroxy agomelatine NEW

Price $58
Package 1mg
Supply Ability: 10g
Update Time: 2026-05-21

Product Details

Product Name: 3-Hydroxy agomelatine CAS No.: 166526-99-4
Purity: 99.97% Supply Ability: 10g
Release date: 2026/05/21

Product Introduction

Bioactivity

Name3-Hydroxy agomelatine
Description3-Hydroxy agomelatine (3-Hydroxyagomelatine) is a 5-HT2C receptor antagonist used in the study of neurological disorders.
In vitroAgomelatine and S 21517 have relatively strong affinity for 5-HT2C receptors, with Ki values of 0.21 μM and 0.13 μM, respectively, while their metabolite 3-Hydroxy agomelatine has a lower affinity, with a Ki value of 1.8 μM, which is about 10-fold lower than that of the former two. All three are antagonists at the 5-HT2C receptor, and the order of potency is S 21517 > agomelatine > 3-Hydroxy agomelatine. [1]
In vivoIn Wistar rats, 3-Hydroxy agomelatine, administered by intraperitoneal injection at doses ranging from 1.25 to 40 mg/kg, did not significantly affect penile erections induced by mCPP and Ro 60-0175. [1]
StorageKeep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 200 mg/mL (771.31 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (19.28 mM), Sonication is recommended.
H2O : 80 mg/mL (308.52 mM), Sonication is recommended.
Keywords5HTReceptor | 5-HT2C Receptor | 5HT Receptor | 3-Hydroxy agomelatine | 3Hydroxy agomelatine | 3 Hydroxy agomelatine
Inhibitors RelatedAlverine citrate | Sevoflurane | Dapoxetine hydrochloride | Cefaclor monohydrate | Clozapine N-Oxide | 1,8-Cineole | Dopamine hydrochloride | Cloperastine hydrochloride | Mianserin hydrochloride | Trazodone hydrochloride | Cinchonidine | Doxepin hydrochloride

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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