3-Hydroxy agomelatine NEW
| Price | $58 | $133 |
| Package | 1mg | 5mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-31 |
Product Details
| Product Name: 3-Hydroxy agomelatine | CAS No.: 166526-99-4 |
| Purity: 99.97% | Supply Ability: 10g |
| Release date: 2026/07/31 |
Product Introduction
Bioactivity
| Name | 3-Hydroxy agomelatine |
| Description | 3-Hydroxy agomelatine (3-Hydroxyagomelatine) is a 5-HT2C receptor antagonist used in the study of neurological disorders. |
| In vitro | Agomelatine and S 21517 have relatively strong affinity for 5-HT2C receptors, with Ki values of 0.21 μM and 0.13 μM, respectively, while their metabolite 3-Hydroxy agomelatine has a lower affinity, with a Ki value of 1.8 μM, which is about 10-fold lower than that of the former two. All three are antagonists at the 5-HT2C receptor, and the order of potency is S 21517 > agomelatine > 3-Hydroxy agomelatine. [1] |
| In vivo | In Wistar rats, 3-Hydroxy agomelatine, administered by intraperitoneal injection at doses ranging from 1.25 to 40 mg/kg, did not significantly affect penile erections induced by mCPP and Ro 60-0175. [1] |
| Storage | Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 200 mg/mL (771.31 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (19.28 mM), Sonication is recommended. H2O : 80 mg/mL (308.52 mM), Sonication is recommended. |
| Keywords | 5HTReceptor | 5-HT2C Receptor | 5HT Receptor | 3-Hydroxy agomelatine | 3Hydroxy agomelatine | 3 Hydroxy agomelatine |
| Inhibitors Related | Ferulic acid sodium | Alverine citrate | Sevoflurane | Dapoxetine hydrochloride | Cefaclor monohydrate | Clozapine N-Oxide | 1,8-Cineole | Cloperastine hydrochloride | Mianserin hydrochloride | Trazodone hydrochloride | Cinchonidine | Doxepin hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compound Library Plus | Neurotransmitter Receptor Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Serotonin Receptor-Targeted Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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